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Guidance cue for cortical radial migration discovered |
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| Abstract: | The regulatory mechanism for neuronal migration in the developing cortex is a major unsolved problem in developmental neurobiology. It is generally accepted that the migration of newborn pyramidal neurons from the ventricular zone toward upper cortical layers is guided by radial glial fibers in the developing cortex, and that the laminar structure of the cortex is formed through regulated attachment and detachment of migrating neurons with radial glial fibers. |
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