Breast cancer in developing population: A nutrition caveat |
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| Authors: | Garima Mehta Seema Kothari P P Singh |
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| Institution: | (1) Department of Surgery, R.N.T. Medical College, 313004 Udaipur;(2) Department of Biochemistry, Darshan Dental College, Loyara, 2313007 Udaipur, India;(3) 375/10 Ashok Nagar, 313001 Udaipur, Rajasthan, India |
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| Abstract: | From January 1992-January 1998, 1404 patients attended the “Breast Clinic” of R.N.T. Medical College M.B. Hospital, Udaipur.
Out of these, 11% and 81% patients had breast cancer (B.C.) and benign breast cancer (B.B.D.) respectively. The oxidative
load in B.C. was 2.32 times higher than controls, but comparable to B.B.D. β-Carotene deficiency was uncommon in patients,
whereas vitamin A deficiency was almost equally common in both B.C. and controls. Most of the patients had almost depleted
levels of α-tocopherol and ascorbic acid but their TBAR levels were in normal range. The data in the present study when compared
with B.B.D. and other local normal subjects point out: a) oxidative burden in B.C. is a consequence and not the cause of the
disease, (b) oxidative stress could be one of the etiological factors in tumor expression, which need not to be malignant
and c) α-tocopherol and ascorbic acid are not importantly responsible for higher oxidative burden in B.C. |
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| Keywords: | Breast Cancer Oxidative Stress Antioxidants α -Tocopherol Ascorbic acid |
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