| 不同级别宫颈上皮内瘤变及宫颈癌患者HPV病毒感染情况研究 |
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| 引用本文： | 陈丽珍,沈菲,林莉萍.不同级别宫颈上皮内瘤变及宫颈癌患者HPV病毒感染情况研究[J].泰州职业技术学院学报,2010,10(5):16-18. |
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| 作者姓名： | 陈丽珍 沈菲 林莉萍 |
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| 作者单位： | 景德镇市第一人民医院妇产科,江西,景德镇,333000 |
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| 摘 要： | 目的探讨各级别宫颈上皮内瘤变及宫颈癌患者HPV病毒感染情况。方法本研究采用TCT联合荧光定量PCR法检测HPV病毒,病理学检查为金标准,TCT筛查正常者为对照组。结果HPV病毒感染率随年龄增加有下降的趋势。HPV-16、58、18三种亚型位居各级别宫颈病变HPV病毒感染的前三位。HPV病毒双重或多重感染与宫颈病变级别之间无正相关性。结论HPV-16、58、18三种亚型致病力强,易导致高级别宫颈病变,具有较高的致癌性。
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| 关 键 词： | 宫颈上皮内瘤变 宫颈癌 人乳头状瘤病毒 液基薄层宫颈刷片细胞学检查 荧光定量PCR法 |
Study on Human HPV Virus Infection in Patients with Different CIN and Uterine Cervix Cancer |
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| CHEN Li-zhen,SHEN Fei,LIN Li-ping.Study on Human HPV Virus Infection in Patients with Different CIN and Uterine Cervix Cancer[J].Journal of Taizhou Polytechnical Institute,2010,10(5):16-18. |
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| Authors: | CHEN Li-zhen SHEN Fei LIN Li-ping |
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| Institution: | (Department of Obstetrics and Gynecology,Jingdezhen No.1 Peoples＇ Hospital, Jingdezhen Jiangxi 333000,China) |
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| Abstract: | Objective To investigate human papillomavirus（HPV） infection in patients with cervical intraepithelial neoplasia（CIN） and uterine cervix cancer.Methods TCT and fluorescent quantitative PCR were applied and the pathological results examined under electronic vaginoscope were the gold standard.The control were those normal patients screened by TCT.Results The rate of HPV virus infection had a descending tendency following with the increasing age.In those cases,the most prevalent of HPV subtypes were HPV-16,-58 and -18.Double or multiple HPV type had no positive relation with different cervical diseases.Conclusion HPV-16,-58 and -18 were highly infectious,which demonstrated that their oncogenesis was stronger and more likely to lead to higher grade cervices disease. |
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| Keywords: | cervical intraepithelial neoplasia（CIN） uterine cervix cancer human papilloma virus（HPV） thinprep cytological test（TCT） fluorescent quantitative PCR |
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