Innate immunity and the 2011 Nobel Prize |
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| Authors: | Mukta Deobagkar-Lele Chetana Bhaskarla Rajkumar Dhanaraju Manikandan Ponnusamy Dipankar Nandi |
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| Institution: | 1. Department of Biochemistry, Indian Institute of Science, Bangalore, 560 012, India
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| Abstract: | The 2011 Nobel Prize inMedicine or Physiology was awarded to Jules Hoffmann, Bruce Beutler and Ralph Steinman for their contributions in the area of Innate Immunity. This review introduces the readers to innate immunity and links the studies of the awardees to this area of research. The cells and mechanisms involved in the innate immune response are reviewed with a special emphasis on the discovery of the Toll receptors in Drosophila and the Toll-like receptors in mammals. The importance of the innate response during inflammatory conditions is discussed and examples of genes related to innate immunity that cause disease are also highlighted. Finally, the roles of innate immunity in modulating adaptive immune response, especially with respect to dendritic cells, are discussed. Further studies in this area are likely to enhance our understanding of the immune response and may lead to drugs to ameliorate excessive inflammatory responses. |
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