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An Investigation into the Parameters Affecting Preparation of Polybutyl Cyanoacrylate Nanoparticles by Emulsion Polymerization |
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| Authors: | Hasan Ebrahimi Shahmabadi Seyed Kazem Bagherpour Doun Seyed Ebrahim Alavi Mehri Mortazavi Zahra Saffari Maryam Farahnak Azim Akbarzadeh |
| Institution: | 1. Pilot Biotechnology Department, Pasteur Institute of Iran, Tehran, Iran 2. Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, Iran 3. Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran |
| Abstract: | Emulsion polymerization was used to synthesize poly butyl cyanoacrylate nanoparticles in presence of steric stabilizer dextran 70. Nanoparticles were characterized by particle size analysis, scanning electron microscopy and light microscopy. Polymerization factors affecting particle size and distribution such as dextran 70, polysorbate 80 (PS 80) and H+ concentration, polymerization time and temperature, and sonication were studied. Distinct concentrations of stabilizer were needed to produce proper nanoparticles. In this case, the appropriate value was 2 % of total volume. At pH 4 significant decrease in production efficiency demonstrated the substantial effect of H+ concentration on nanoparticles. Furthermore significant increases in particle size and distribution was observed at 50 °C compared to room temperature. 0.001 % (v/v) PS 80 represented notable influence on size and distribution. In addition, shaped nanoparticles were obtained by altering polymerization time from 5.5 h to 18 h. Finally, nanoparticle features were influenced by different factors. Appropriate manipulating of such factors can lead to obtaining desirable nanoparticles. |
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