| 膜分离技术在霉酚酸提取中的应用 |
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| 引用本文： | 林丽华.膜分离技术在霉酚酸提取中的应用[J].鹭江职业大学学报,2014(5):107-112. |
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| 作者姓名： | 林丽华 |
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| 作者单位： | 三达膜环境技术股份有限公司,福建 厦门361021 |
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| 摘 要： | 利用陶瓷膜和纳滤膜的组合分离技术代替板框对霉酚酸发酵液的过滤,对霉酚酸发酵液进行澄清和浓缩实验.采用陶瓷膜（0．1μm）和S-372纳滤膜技术对霉酚酸发酵液进行研究,研究了膜系统的通量、加水倍数和浓缩倍数等因素对膜分离性能的影响.在陶瓷膜加水4倍时,霉酚酸的收率可达96．5%,平均通量可达160-180 L/（ m2·h）；纳滤对霉酚酸的截留率和收率均达到98%,霉酚酸效价可浓缩到21 g/L,通量为25 L/（ m2·h）左右,与板框滤液效价相比,提高了3．5倍.结果表明：陶瓷膜和纳滤膜的组合工艺在产品收率及产品质量方面都明显优于传统的板框过滤,具有良好的应用潜力.
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| 关 键 词： | 霉酚酸 陶瓷膜 纳滤 提取 |
Membrane Technique for Mycophenolic Acid Extraction |
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| LIN Li-hua.Membrane Technique for Mycophenolic Acid Extraction[J].Journal of Lujiang University,2014(5):107-112. |
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| Authors: | LIN Li-hua |
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| Institution: | LIN Li-hua ( Suntar Environmental Technology Co., Ltd., Xiamen 361021, China) |
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| Abstract: | The ceramic nanofiltration membrane technology was introduced to replace plat and frame filtration to clarify and concentrate the mycophenolic acid. Ceramic membrane （ 0. 1 μm ） and S - 372 nanofiltration membrane were used to study the impact of flux, water addition or concentration on membrane separation performance. When four times of water is added, the yield of mycophenolic acid is 96. 5% and the membrane flux is about 160 ~180 L/（ m2·h） , the retention rate and the yield of mycophenolic acid of nanofiltration process are 98%, mycophenolic acid can be concentrated to about 21 g/L with the flux standing at about 25 L/（ m2·h） , 3. 5 times better than plat and frame filtration. The results show that ceramic nanofiltration membranes are significantly better than plate and frame filter in product yield and product quality and enjoy a good prospect for application. |
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| Keywords: | mycophenolic acid ceramic membrane nanofiltration extraction |
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