Effect of calcium channel blockers on stress-induced visceral, endocrinological and immune responses |
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| Authors: | P K Mediratta K K Sharma S G Chowdhury |
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| Institution: | (1) Department of Pharmacology, University College of Medical Sciences and G.T.B. Hospital, 110 095 Delhi |
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| Abstract: | In the present study effects of five commonly used calcium channel blockers (CCBs) belonging to different chemical classes
have been investigated on stress-induced modulation of some visceral, endocrinological and immunological parameters in rats
and mice. Restraint stress (RS) produced gastric mucosal lesions, increased plasma corticosterone levels and reduced antiSRBC
antibody titre, a measure of humoral immune response and % leucocyte migration inhibition (% LMI) and foot pad thickness,
measures of cell-mediated immunity. Nimodipine (10, 20 40 mg/kg, i.p.) and flunarizine (10, 20, 40 mg/kg, i.p.) antagonised
the effect of RS on gastric ulcerogenesis and plasma corticosterone levels but failed to modulate the stress-induced suppression
of both humoral and cell-mediated immune responses. Thus, CCBs appear to modulate stress-induced visceral, endocrinological
and immune responses, albeit in a differential manner. |
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| Keywords: | Restraint stress Gastric ulcerogenesis Corticosterone levels Immune responses |
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