| 有氧运动影响动脉粥样硬化的动物模型实验研究 |
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| 引用本文： | 袁凌燕,陆爱云,张胜年,陆耀飞,杨萍,舒娉.有氧运动影响动脉粥样硬化的动物模型实验研究[J].上海体育学院学报,2006,30(4):45-49. |
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| 作者姓名： | 袁凌燕 陆爱云 张胜年 陆耀飞 杨萍 舒娉 |
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| 作者单位： | 上海体育学院,运动科学系,上海,200438 |
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| 摘 要： | 采用主动脉大体染色、HE染色等实验方法,根据病理形态判断AS(动脉粥样硬化)模型的建立,根据资料和小鼠体重、饮食、运动状况等生长情况判断运动量,对这一双重模型的合理性进行判断。结果:采用的大体染色、体视显微镜下显示ApoE-/-小鼠(8周龄ApoE基因敲除鼠)主动脉弓、分支口、腹主动脉均出现斑块,HE染色显示ApoE-/-小鼠形成了典型成熟的粥样斑块。结论:采用的ApoE-/-小鼠建立AS模型理想、稳定,采用的运动方案合理,运动量适中。
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| 关 键 词： | 动脉粥样硬化 有氧运动模型 动物模型 病理形态 ApoE-/-小鼠 |
| 文章编号： | 1000-5498（2006）04-0045-05 |
| 收稿时间： | 2006-03-10 |
| 修稿时间： | 2006-05-17 |
Experimental Study of Effect of Aerobic Exercise on Atherosclerosis Animal Model |
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| YUAN Ling-yan,LU Ai-yun,ZHANG Sheng-nian,LU yao-fei,YANG Ping,SHU Ping.Experimental Study of Effect of Aerobic Exercise on Atherosclerosis Animal Model[J].Journal of Shanghai Physical Education Institute,2006,30(4):45-49. |
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| Authors: | YUAN Ling-yan LU Ai-yun ZHANG Sheng-nian LU yao-fei YANG Ping SHU Ping |
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| Institution: | Sports Science Dept., Shanghai University of Sport, Shanghai, 200438, China |
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| Abstract: | It used the experimental method of aorta section staining,HE staining etc.to judge the establishment of atherosclerosis(AS) model from pathomorphology,judge training load from related material and mice's body weight,diet,exercise state etc.and judge the reasonability of this double model.The results indicate that the spots have been detected in arota arch,arota branch and abdorminal arota of ApoE~(-/-) mice(eight-week-old knock-out mice).Moreover HE staining reveals that the typical and ripe atheromatous plaques have been formed.It concludes that the selected AS model established with ApoE~(-/-) mice is ideal and steady and the exercise scheme used is feasible and medium in traning load. |
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| Keywords: | atherosclerosis aerobic exercise model animal model pathomorphology ApoE~(-/-) mice |
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