Effect of corticosteroids on elevated intracellular sodium, plasma lipid peroxide levels and reduced Na+, K+-ATPase activity in patients of bronchial asthma |
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| Authors: | A Sondhi B Talukdar |
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| Institution: | (1) Biochemistry Department, Maulana Azad Medical College, N. Delhi |
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| Abstract: | In view of several reports that there is a lack of balance in free radicals in case of bronchial asthma (1) the effect of
free radicals on cell membrane was studied by estimating the membrane bound protein Na+, K+-ATPase activity and the intracellular sodium level in patients of bronchial asthma before and after a short course (one week)
of oral corticosteroid (prednisolone 0.75–1mg/kg body weight) therapy. Results showed that there is a definite statistically
significant rise in free radical level and intracellular sodium level and a significant lowering of Na+, K+-ATPase activity in case of untreated bronchial asthma. After short course of therapy with oral corticosteroids, the free
radical level and intracellular sodium level decreased significantly, together with a significant rise of the Na+, K+-ATPase activity. Also, a significant negative correlation (r=−0.74) between the lipid peroxide level and the Na+,-K+-ATPase activity was found in these cases. |
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| Keywords: | Corticosteroid Na+ K+-ATPase Lipid Peroxide |
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