| 上皮性卵巢癌中Skp2蛋白的表达及临床意义 |
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| 引用本文： | 刘云春,魏荣英,李建平.上皮性卵巢癌中Skp2蛋白的表达及临床意义[J].河北北方学院学报(医学版),2006,23(2):24-26. |
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| 作者姓名： | 刘云春 魏荣英 李建平 |
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| 作者单位： | 河北北方学院附属第一医院妇产科,河北,张家口,075000 |
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| 摘 要： | 目的：探讨Skp2蛋白表达与上皮性卵巢癌发生、发展及预后评价的意义。方法：采用免疫组化法检测15例卵巢上皮性良性肿瘤、10例卵巢上皮性交界性肿瘤及58例上皮性卵巢癌中Skp2蛋白的表达情况。结果：Skp2在卵巢上皮性良性及交界性肿瘤中的表达均为阴性，而在上皮性卵巢癌中高表达，阳性率为48．28％（28／58），Skp2在中低分化组、Ⅲ／Ⅳ期组及有淋巴结转移组分别高于高分化组（P〈0．01）、Ⅰ／Ⅱ期组（P〈0．01）及无淋巴结转移组（P〈0．01）。在不同年龄及组织类型的卵巢癌中表达无显著性差异。结论：Skp2在上皮性卵巢癌中表达，表达水平越高提示预后越差。
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| 关 键 词： | 卵巢癌 临床分期 病理分级 预后 |
| 文章编号： | 1673-1484(2006)02-0024-03 |
Clinical Significance and Expression of Skp2 Protein in Ovarian Epithelial Tumors |
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| LIU Yun-chun,WEI Rong-ying,LI Jian-ping.Clinical Significance and Expression of Skp2 Protein in Ovarian Epithelial Tumors[J].Journal of Hebei North University:Medical Edition,2006,23(2):24-26. |
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| Authors: | LIU Yun-chun WEI Rong-ying LI Jian-ping |
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| Abstract: | Objective:To investigate expression of Skp2 protein in ovarian epithelial tumors and its clinical significance.Methods:Test ovarian epithelian tumor tissues of 83 cases with monoclonal antibody Skp2 by immunohistochemistry.Results: The rate of positive expression of Skp2 was 48.28% in ovarian epithelial cancers.No expression of gene protein appeared in borderline and benign ovarian tumor tissues.Conclusion: Skp2 gene participate in origination and development of ovarian epithelial cancers,and higher expression of Skp2 indicats worse prognosis. |
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| Keywords: | Skp2 |
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