Clinical usefulness of alterations in sialic acid,sialyl transferase and sialoproteins in breast cancer |
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| Authors: | G N Raval L J Parekh D D Patel F P Jha R N Sainger P S Patel |
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| Institution: | (1) Biochemistry Research Division, The Gujarat Cancer & Research Institute, Asarwa, 380 016 Ahmedabad, India;(2) Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, India |
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| Abstract: | Sialic acid, the end moieties of the carbohydrate chains are biologically important and essential for functions of glycoconjugates
and are reported to be altered in cancer patients. Two hundred and twenty five breast cancer (BC) patients, 100 patients with
benign breast disease (BBD) and 100 healthy females (controls) were enrolled for the study. Eight hundred and twenty four
follow-up samples of 225 breast carcinoma patients were also evaluated. The association of sialic acid forms, sialyltransferase
and α-2–6 sialoproteins levels with presence and extent as well as prognosis of breast carcinoma was studied. Serum sialic
acid forms and sialyltransferase revealed significantly elevated levels among untreated breast cancer patients as compared
to the controls, patients with BBD as well as cancer patients in remission. Non-responders showed comparable levels of the
markers with those found in breast cancer patients at the time of diagnosis. Higher levels of sialic acid forms at diagnosis
were associated with poor prognosis. A positive correlation between serum levels of different forms of sialic acids and extent
of malignant disease was observed. The changes in serum proteins with terminal α-2–6 sialic acid correlated well with alterations
in the levels of sialic acid forms and sialyltransferase. Malignant tissues showed elevated levels of sialic acid and sialyltransferase
as compared to surrounding normal tissues.
The results suggested potential utility of these markers in evaluation of clinical outcome. |
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| Keywords: | Breast Cancer Glycoproteins Sialic acid Sialyltransferase Tumours |
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