Hyperhydration using different hydration agents does not affect the haematological markers of the athlete biological passport in euhydrated volunteers期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Hyperhydration using different hydration agents does not affect the haematological markers of the athlete biological passport in euhydrated volunteers

Authors:	Ioanna Athanasiadou Sven Christian Voss Wesal El Saftawy Mohammed Al-Maadheed Georgia Valsami Costas Georgakopoulos

Institution:	1. Anti-Doping Lab Qatar , Doha, Qatar;2. Laboratory of Biopharmaceutics &3. Pharmacokinetics, Department of Pharmacy, School of Health Sciences, National &4. Kapodistrian University of Athens , Athens, Greece ioanna.athanasiadou@gmail.comhttps://orcid.org/0000-0002-7909-1202;6. Anti-Doping Lab Qatar , Doha, Qatar;7. Kapodistrian University of Athens , Athens, Greece;8. Anti-Doping Lab Qatar , Doha, Qatar https://orcid.org/0000-0001-5744-1243

Abstract:	ABSTRACT Athlete Biological Passport (ABP) is an indirect approach, implemented by WADA, aimed at detecting blood manipulation based on abnormal changes in haematological markers. Cases report the use of hyperhydration as masking method during anti-doping urine sample collection which could potentially mask suspicious fluctuations on ABP profiles. This study investigated the hyperhydration effect on haemoglobin concentration, reticulocyte percentage and OFF-hr score (an algorithm based on haemoglobin concentration and reticulocyte percentage), with and without recombinant human erythropoietin (rHuEPO) administration. A five-week clinical study performed; Baseline and rHuEPO Phase. Water and a sports drink were used as hyperhydration agents. To examine the hyperhydration effect on the normal ABP profile per volunteer, hyperhydration was implemented at 0, 24 and 48 hours during the baseline. During the rHuEPO phase, volunteers received Epoetin beta (3000 IU) with hyperhydration to be implemented at 0, 24 and 48 hours after drug administration. Blood and urine samples were collected and analysed according to WADA guidelines. No significant effect on ABP markers was observed due to hyperhydration at any time during the study. Pre- and post-hyperhydration data were not statistically different compared to individual baseline data. In conclusion, hyperhydration does not affect the ABP haematological markers under the examined conditions.

Keywords:	Athletes Biological Passport erythropoietin hyperhydration blood doping

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