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Study of Toxicity Effect of Pegylated Nanoliposomal Artemisinin on Breast Cancer Cell Line |
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| Authors: | Neda Dadgar Seyed Ebrahim Alavi Maedeh Koohi Moftakhari Esfahani Azim Akbarzadeh |
| Institution: | 1. Department of Agricultural Biotechnology, Science and Research Branch, Islamic Azad University, Tehran, Iran 2. Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran 3. Department of Pilot Biotechnology, Pasteur Institute of Iran, Tehran, Iran |
| Abstract: | Nano carriers have greatly revolutionized the treatment of most diseases recently. One of these nano carriers, liposomes, has got particular significance. On the other hand, Artemisinin which is used as an effective anticancer drug has some side effects. To reduce such side effects, liposomes can be employed. In order to prepare pegylated nanoliposomal artemisinin, particular proportions of phosphatidylcholine, polyethylene glycol 2000 and artemisinin were combined. As a result, the mean diameter of nano liposomes is 455 nm. Besides, the encapsulation efficiency and the drug release from pegylated nanoliposomes for pegylated nanoliposomal artemisinin are respectively 91.62 ± 3.5 and 5.17 %. The results also show that IC50 of the produced formulation is less than that of the standard drug. This study reveals that the amount of artemisinin cytotoxicity compared to standard drug is increased by pegylated nanoliposomal formulation. |
| Keywords: | Artemisinin Nanoliposome Breast cancer Pegylation |
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