Effects of Nanoliposomal and Pegylated Nanoliposomal Artemisinin in Treatment of Breast Cancer |
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| Authors: | Neda Dadgar Maedeh Koohi Moftakhari Esfahani Sepideh Torabi Seyed Ebrahim Alavi Azim Akbarzadeh |
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| Institution: | 1. Department of Agricultural Biotechnology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2. Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, No 358, 12 Farvardin Street, Jomhoori Avenue, 13169-43551, Tehran, Iran
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| Abstract: | This study is aimed to investigate the nanoliposomal artemisinin preparation, and its implementation on breast cancer cells. Side effects have been one of the common challenges of drug usage, as well as cancer treatment. In order to reduce such effects, nanotechnology has been a great help. Nanoliposomes are provided through reverse phase evaporation. In this method, certain proportions of phosphatidylcholine, cholesterol and artemisinin were mixed together. Besides, the obtained formulation was pegylated by using polyethylene glycol 2000 in order to increase its stability and solubility. The mean diameter of non-pegylated and pegylated liposomal artemisinin was determined by Zeta sizer system. The percent of drug released from liposome was performed by dialysis. The encapsulation efficiency of both formulations was estimated by spectrophotometry method. As a result, encapsulation and drug release of nanoliposomal formulation were more than the pegylation of the same formulation. In addition, this study indicated that cytotoxicity effect of pegylated nanoliposomal artemisinin was more, in comparison with nanoliposomal artemisinin. |
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| Keywords: | Artemisinin Nanoliposome Breast cancer Drug delivery Cytotoxicity |
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