Analyzing and modeling rheological behavior of liver fibrosis in rats using shear viscoelastic moduli |
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| Authors: | Ying Zhu Yi Zheng Yuan-yuan Shen Xin Chen Xin-yu Zhang Hao-ming Lin Yan-rong Guo Tian-fu Wang Si-ping Chen |
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| Institution: | 1. National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518160, China
2. Department of Electrical and Computer Engineering, St. Cloud State University, St. Cloud, MN, 56301, USA
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| Abstract: | The process of liver fibrosis changes the rheological properties of liver tissue. This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli. Here two viscoelastic models, the Zener model and Voigt model, were applied to experimental data of rheometer tests and then values of elasticity and viscosity were estimated for each fibrosis stage. The results demonstrate that moderate fibrosis (≤F2) has a good correlation with liver viscoelasticity. The mean Zener elasticity E 1 increases from (0.452±0.094) kPa (F0) to (1.311±0.717) kPa (F2), while the mean Voigt elasticity E increases from (0.618±0.089) kPa (F0) to (1.701±0.844) kPa (F2). The mean Zener viscosity increases from (3.499±0.186) Pa·s (F0) to (4.947±1.811) Pa·s (F2) and the mean Voigt viscosity increases from (3.379±0.316) Pa·s (F0) to (4.625±1.296) Pa·s (F2). Compared with viscosity, the elasticity shows smaller variations at stages F1 and F2 no matter what viscoelastic model is used. Therefore, the estimated elasticity is more effective than viscosity for differentiating the fibrosis stages from F0 to F2. |
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| Keywords: | Biological mechanics Rheological properties Liver fibrosis Viscoelasticity Shear modulus Elasticity Viscosity Zener model Voigt model |
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