| 不同运动时间对2型糖尿病大鼠骨骼肌Glut-4含量变化的研究 |
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| 引用本文： | 薛伟善.不同运动时间对2型糖尿病大鼠骨骼肌Glut-4含量变化的研究[J].沈阳体育学院学报,2012,31(4):83-85. |
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| 作者姓名： | 薛伟善 |
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| 作者单位： | 辽宁师范大学体育学院,辽宁大连,116029 |
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| 摘 要： | 为了解运动强度相同而运动时间不同对鼠肌葡萄糖载体-4(Glut-4)蛋白表达及含量的影响,采用制备糖尿病大鼠模型方法将SD大鼠分为正常对照组、糖尿病对照组、糖尿病运动组(20min组、40min组、60min组和80min组)等6组,以20m/min的强度进行8周的跑台运动,用Western blot免疫印迹法检测运动后GLUT-4蛋白含量。结果表明,与糖尿病对照组相比,运动时间20min、40min组、60min组和80min组的股四头肌Glut-4蛋白含量显著升高(P<0.01);与20min组相比,运动时间40min组、60min组及80min组的Glut-4蛋白含量显著升高(P<0.01),认为运动时间对Glut-4蛋白含量产生明显的影响,运动时间达40min以上可能具有更好的效果。
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| 关 键 词： | 不同运动时间 2型糖尿病大鼠 Glut-4含量 |
Effects of Different Times' Exercise on Glut-4 Content in Skeletal Muscle of Type 2 DM Rats |
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| XUE Weishan.Effects of Different Times' Exercise on Glut-4 Content in Skeletal Muscle of Type 2 DM Rats[J].Journal of Shenyang Sport University,2012,31(4):83-85. |
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| Authors: | XUE Weishan |
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| Institution: | XUE Weishan(Physical Education Institute of Liaoning Normal University,Dalian 116029,Liaoning,China) |
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| Abstract: | Objective:To explore the effects of different times’exercise on GLUT-4 protein content in type 2 DM rats.Method:Sixty SD rats were divided into six groups:normal control group(NC)、diabetes mellitus group(DMC)and 20min、40min、60min and 80min exercise group.The exercise groups did exercise for 8 weeks.The contents of GLUT-4 protein were measured by Western bolt analysis.Result:The contents of IRS-2 protein in 20min,40min,60m/min and 80min group enhanced(P<0.01)respectively compare with the DMC group,and 40min,60min and 80min group enhanced(P<0.01)compare with 20min group.Conclusion:The results showed that the exercise times have affected the contents of GLUT-4 protein,exercise times over 40min may have the better effect. |
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| Keywords: | different times’exercise type 2 diabetic rat GLUT-4 content |
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