Sex hormone binding globulin in breast cancer |
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| Authors: | Dayalu Naik S L Suresh Hedau Anil Kumar Bahadur Renuka Saha Sudershan Kaur Amitabha Ray |
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| Institution: | (1) Institute of Cytology and Preventive Oncology, 1-7, Sector-39, Noida, 201 301, India;(2) Department of Radiotherapy, Maulana Azad Medical College, New Delhi, 110 002, India;(3) Department of Preventive and Social Medicine, Maulana Azad Medical College, New Delhi, 110 002, India;(4) The Hormel Institute, University of Minnesota, 801-16th Avenue NE, Austin, MN 55912, USA;(5) Division of Molecular Oncology, Institute of Cytology and Preventive Oncology, I-7, Sector-39, Noida, 201 301, India |
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| Abstract: | The present study was undertaken to determine the significance of sex hormone binding globulin, the major and specific binding
protein for testosterone and estradiol, in breast cancer. Among breast cancer patients, lower serum levels of Sex hormone
binding globulin and higher levels of testosterone were observed. Sex hormone binding globulin showed an inverse relationship
with testosterone and total cholesterol, and a direct relation with HDL-cholesterol. By the western blot analyses, Sex hormone
binding globulin was detected in all biological samples that we examined. In the breast tumor tissue sections, immuno-staining
for Sex hormone binding globulin was confined in cell cytoplasm and 29% cases were positive, which showed no association with
the investigated prognostic markers of breast cancer such as ER and HER-2/neu over-expression. In this study, decreased circulating
levels of Sex hormone binding globulin in breast cancer patients possibly indicate higher bioavailable estrogens. |
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| Keywords: | Breast cancer Menopausal status Sex hormone binding globulin Hormones |
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