| 分段逆向调强优化方法在乳腺癌调强放疗计划设计中的应用研究 |
| |
| 引用本文： | 靳富,柳先锋,何亚男,杨勇,王颖.分段逆向调强优化方法在乳腺癌调强放疗计划设计中的应用研究[J].中国科技信息,2012(17):48-49. |
| |
| 作者姓名： | 靳富 柳先锋 何亚男 杨勇 王颖 |
| |
| 作者单位： | 重庆市肿瘤研究所放射治疗科,重庆,400030 |
| |
| 摘 要： | 目的:制作乳腺癌调强放疗计划时,采用分段逆向调强优化方法以达到更好的靶区剂量和保护肺、心脏等危及器官。方法:应用Eclipse8.6计划系统针对10例乳腺癌患者(肿瘤原发部位左右侧各5例)分别制定T1,T2模式调强放疗计划,处方剂量均为DT50Gy/25次。T1模式采用左乳300°、330°、0°、30°、60°、90°和120°方向射野,右乳60°、30°、0°、330°、300°、270°和240°方向射野,设置优化参数进行逆向优化和剂量运算。T2模式采用与T1模式相同的角度方向设野,第一段总剂量24Gy,分次剂量2Gy,分12次治疗,设置优化参数进行逆向优化和剂量运算;第二段总剂量26Gy,分次剂量2Gy,分13次照射,设置优化参数,采用"Base dose plan"功能选择基于第一段治疗计划以总量50Gy来逆向优化和剂量运算。将两段计划相加作为T2模式的治疗计划,通过剂量体积直方图比较两种模式下计划的靶体积和危及器官剂量分布。结果:T1、T2模式调强放疗计划的靶体积均满足临床剂量要求,对于左侧乳腺癌,适形指数分别为0.727±0.034、0.751±0.034(t=-6.20,P=0.003);对于右侧乳腺癌,适形指数分别为0.691±0.058、0.729±0.048(t=-5.39,P=0.006)。对左侧乳腺癌,T2模式的左肺V10(%)、左肺V20(%)、左肺V30(%)、全肺V10(%)、全肺V20(%)、全肺V30(%)和心脏V10(%)均大于T1模式,分别增大5.0%、2.7%、3.7%、4.6%、2.6%、3.8%和4.4%。对于右侧乳腺癌,无充分证据说明危及器官各指标有差别。结论:与T1模式相比,采用分段逆向调强优化方法能更好的优化靶区的剂量分布,但对左侧乳腺癌而言,会略微增加左肺、全肺和心脏剂量受量。
|
| 关 键 词： | 乳腺癌 放射疗法 调强 剂量 |
An applied research of segmented inverse-planned intensity-modulated radiotherapy for breast cancer |
| |
| Jin Fu
,
Liu Xianfeng
,
He Yanan
,
Yang Yong
,
Wang Ying.An applied research of segmented inverse-planned intensity-modulated radiotherapy for breast cancer[J].CHINA SCIENCE AND TECHNOLOGY INFORMATION,2012(17):48-49. |
| |
| Authors: | Jin Fu Liu Xianfeng He Yanan Yang Yong Wang Ying |
| |
| Institution: | * Department of Radiation Oncology,Chongqing Cancer Institute,Chongqing,400030,China. |
| |
| Abstract: | To achieve better target dose coverage and protection of the lung,heart and other organs at risk using segmented inverse treatment planning when making plans of intensity-modulated radiation therapy for breast cancer.Methods: We developed T1,T2 mode intensity-modulated radiation therapy plans respectively for 10 cases of breast cancer(5 cases for each side) in Eclipse 8.6.The total prescribed dose was 50Gy/25 fractions for both sets of planning.Mode T1: The angles of seven coplanar beams were 300 °,330 °,0 °,30 °,60 °,90 ° and 120 °respectively for left side breast cancer,and 60 °,30 °,0 °,330 °,300 °,270 ° and 240 °respectively for right side breast cancer.Also we set the optimal parameters for inverse optimization and dose calculation.Mode T2: The beam angles and parameters were as the same as mode T1,but split 50Gy/25 into two parts to do two treatment plans respectively,and the total prescribed dose for the first plan is 24Gy/12 fractions;the total prescribed dose for the second plan is 26Gy/13 fractions,and adopt the total dose of 50Gy to redo optimization and dose calculation by using "Base dose plan" to select the first plan as base plan.The sum of two plan set as mode T2’s plan.With the dose volume histogram we compared the dose distribution of the target volume and organs at risk dose between two modes.Results: Target dose coverage in both mode T1 and T2 could be clinically accepted,and the CI were 0.727±0.034 and 0.751±0.034(t=6.20,P=0.003)for the left breast cancer,and the CI were 0.691±0.058 and 0.729±0.048(t=-5.39,P=0.006)for the right breast cancer.For the left breast cancer,the left lung V10(%),left lung V20(%),left lung V30(%),total lung V10(%),total lung V20(%),total lung V30(%) and heart V10(%) of T2 mode were greater than T1 mode,increased 5.0%,2.7%,3.7%,4.6%,2.6%,3.8% and 4.4% respectively.For the right breast,there wasn’t sufficient evidence to confirm the difference between each index for two modes.Conclusion: Compared with the T1 mode,T2 mode could have better target dose distribution.For the left breast cancer,the dose would be increased slightly for the left lung,total lung and heart. |
| |
| Keywords: | breast cancer radiation therapy IMRT dose |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
