Effect of vitamin E supplementation on oxidative stress in hemodialysis patients |
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| Authors: | R B Bhogade A N Suryakar N G Joshi R Y Patil |
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| Institution: | (1) Department of Biochemistry, P.D.U. Dental College, Solapur, India;(2) Department of Biochemistry, Dr. V. M. Govt. Medical College, Solapur, India;(3) College of Pharmacy, Solapur, India;(4) Department of Biochemistry, Dr. V. M. Govt. Medical College, Solapur, 413003, Maharashtra, India |
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| Abstract: | Hemodialysis represents a chronic stress status for its recipients. Many hypotheses state that this may be associated with
oxidative stress. Thus, there may be deficiency of antioxidants like erythrocytic superoxide dismutase, catalase, vitamin
E or increased generation of free radicals like superoxide anions. A study was carried out to investigate oxidant and antioxidant
status in chronic renal failure patients undergoing hemodialysis and effect of vitamin E supplementation on these two status.
Blood samples were collected from patients before and after hemodialysis and from controls. The samples were analyzed for
quantitation of MDA as index of lipid peroxide, nitric oxide, vitamin E, vitamin C and enzymatic antioxidants namely erythrocyte
SOD and catalase. As compared to controls, the levels of serum MDA were significantly increased and activities of erythrocyte
SOD and catalase, levels of serum nitric oxide, serum vitamin E and plasma vitamin C were significantly decreased both before
and after hemodialysis. The efficiency of vitamin E therapy in hemodialysis patients was assessed by re-evaluating oxidant
and antioxidant status of same patients after supplementation of vitamin E. Vitamin E supplementation caused decrease in serum
MDA and increase in levels of serum nitric oxide, vitamin E, vitamin C and activities of erythrocytic SOD and catalase. Our
results suggest the presence of oxidative stress and the possible preventive role of vitamin E therapy in hemodialysis patients. |
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| Keywords: | Hemodialysis Oxidative stress Antioxidant Vitamin E MDA Erythrocytic SOD |
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