| 3-氯-2硝基甲苯的合成 |
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| 引用本文： | 冯荣秀,宋健,陈磊,马丽,张静,孙国鹏.3-氯-2硝基甲苯的合成[J].天津大学学报(英文版),2002,8(1):40-42. |
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| 作者姓名： | 冯荣秀 宋健 陈磊 马丽 张静 孙国鹏 |
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| 作者单位： | 天津大学药物科学与技术学院,天津,300072 |
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| 摘 要： | 以 2 ,6 二氯苯胺为原料 ,通过重氮化反应、取代反应、缩合反应与脱羧反应得到 3 氯 2 硝基甲苯的合成路线 ,确定了最佳反应条件 ,以 2 ,6 二氯苯胺为原料制取 2 ,6 二氯硝基苯 ,收率为 78.9% ;在N ,N 二甲基甲酰胺中以碳酸钾为催化剂 ,2 ,6 二氯硝基苯与氰基乙酸甲酯反应制取 2 氰基 2 (3′ 氯 2′ 硝基苯基 )乙酸甲酯 ,收率为 80 .2 % ;第三步通过水解反应获得 3 氯 2 硝基苯基乙酸 ,收率为 82 .6 % ;3 氯 2 硝基苯基乙酸通过脱羧反应得到最终产品 3 氯 2 硝基甲苯 ,产率为 72 .9% .采用红外光谱和核磁共振谱对产品进行了定性分析
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| 关 键 词： | 3氯2硝基甲苯 2 6二氯苯胺 合成 |
Synthesis of 3-Chloro-2-Nitrotoluene |
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| FENG Rongxiu,SONG Jian,CHEN Lei,MA Li,ZHANG Jing,SUN Guopeng.Synthesis of 3-Chloro-2-Nitrotoluene[J].Transactions of Tianjin University,2002,8(1):40-42. |
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| Authors: | FENG Rongxiu SONG Jian CHEN Lei MA Li ZHANG Jing SUN Guopeng |
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| Abstract: | The synthesis of 3-chloro-2-nitrotoluene using 2,6-dichloroaniline as starting material by diazotization, substitution, condensation, decarboxylic reaction was studied and the best conditions of the synthetic procedures were confirmed. Dichloronitrobenzene was obtained in 78.90 0 yield based on 2,6-dichloroaniline. The reaction of 2,6-dichloronitrobenzene and methyl cyanoacetate with potassium carbonate catalyst in N,N-dimethyl formamide gave methyl 2-cyano-2-(3′-chloro-2′-nitrophenyl) acetate in 80.20 0 yield. The third procedure product 3-chloro-2-nitrophenylacetic acid was obtained by hydrolysis in 82.60 0 yield. Decarboxylation reaction of 3-chloro-2-nitrophenylacetic acid produced 3-chloro-2-nitrotoluene in 72.90 0 yield.The structure of products was identified by IR and NMR. |
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| Keywords: | chloro 2 nitrotoluene 2 6 dichloroaniline synthesis |
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