| 抑制mTOR的抗肿瘤药物的研究进展 |
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| 引用本文： | 张辉,胡逢恺.抑制mTOR的抗肿瘤药物的研究进展[J].黄山学院学报,2007,9(3):66-70. |
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| 作者姓名： | 张辉 胡逢恺 |
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| 作者单位： | 黄山学院,化学系,安徽,黄山,245041 |
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| 基金项目： | 黄山学院自然科学研究项目(2006xkj004) |
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| 摘 要： | mTOR受体蛋白是真核细胞中存在的一种PIKK类的激酶,它在细胞分裂、分化、生存中起着核心的作用,对mTOR的抑制将使细胞停滞于G1期或使细胞凋亡。现在已经开发出来的mTOR抑制剂有雷帕霉素衍生物、吡咯并喹啉衍生物及色酮类衍生物,它们的活性研究表明mTOR抑制剂有望成为一类新型抗肿瘤药物。
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| 关 键 词： | mTOR 雷帕霉素 PIKK FKBP 吡咯并喹啉 色酮 |
| 文章编号： | 1672-447X（2007）03-0066-05 |
| 修稿时间： | 2007-01-16 |
Sudy on the Development of mTOR Inhibitors of Anti-Tumor Medicine |
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| Zhang Hui,Hu Fengkai.Sudy on the Development of mTOR Inhibitors of Anti-Tumor Medicine[J].Journal of Huangshan University,2007,9(3):66-70. |
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| Authors: | Zhang Hui Hu Fengkai |
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| Institution: | Department of Chemistry, Huangshan University, Huangshan245041, China |
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| Abstract: | The mTOR receptor protein is a sort of PIKK kinases existing in the eukaryotic cell.It plays a core role in the cell division,differentiation and survival.The mTOR suppression will cause G1- arresting or perishing to the cells.Currently,we have already developed rapamycin derivatives,the pyrrole- quinoline derivatives and the colorketones derivatives as mTOR inhibitor.Studys on Reactivity of these mTOR inhibitors indicate they have much prospect to be a new kind of anti-tumor medicine. |
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| Keywords: | mTOR rapamycin PIKK FKBP pyrrole-quinoline colorketones |
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