Effect of herbal hypoglycemic agents on oxidative stress and antioxidant status in diabetic rats |
| |
| Authors: | Abbas Ali Mahdi Anu Chandra Raj Kumar Singh Sanjeev Shukla L C Mishra Sohail Ahmad |
| |
| Institution: | (1) Faculty of Life Sciences, C.S.J.M. University, Kanpur;(2) Department of Pharmacology, State Govt. T.T. College, Lucknow, U.P., India;(3) Department of Biochemistry, C.S.M. Medical University (upgraded King George's Medical College), 226003 Lucknow, U.P., India |
| |
| Abstract: | In the present study the antioxidative potential ofMomordica charantia, Azadirachta indica, Allium sativum andOcimum sanctum was assessed in streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated
animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups
as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed
when the above herbal hypoglycemic agents were given to diabetic rats. On the basis of our results we conclude thatM. charantia, A. indica, A. sativum andO. sanctum are not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant
potential. |
| |
| Keywords: | Free radicals diabetes mellitus antioxidants herbal hypoglycemic agents |
| 本文献已被 SpringerLink 等数据库收录！ |
|
