| 顶空色谱法测定琥珀酸美托洛尔中残留溶剂的研究 |
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| 引用本文： | 党民团,张雪妮.顶空色谱法测定琥珀酸美托洛尔中残留溶剂的研究[J].渭南师范学院学报,2014(23):29-32. |
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| 作者姓名： | 党民团 张雪妮 |
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| 作者单位： | 渭南师范学院化学与生命科学学院,陕西渭南,714099 |
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| 基金项目： | 陕西省教育厅科研计划项目渭河湿地生态环境研究(2014JK1253)；渭南师范学院重点科研计划项目渭南市郊蔬菜种植区重金属污染状况及健康风险分析 |
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| 摘 要： | 建立了顶空－气相色谱法检测琥珀酸美托洛尔中残留溶剂（丙酮和异丙醇）的测定方法．被测样品的各个组分在非极性弹性石英毛细管柱上能有效分离；在0．001～0．300 mg／mL浓度范围内，线性相关系数R≥0．9990；加标回收率为90．73％～104．80％，相对标准偏差为0．76％～11．85％（ n＝5），方法的检出限为2．00μg／mL．该方法检测琥珀酸美托洛尔中的残留溶剂重现性好，定量准确，便于操作．
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| 关 键 词： | 顶空-气相色谱法 琥珀酸美托洛尔 残留溶剂 |
Research about the Detection to Residual Solvents that Remains in Metroprolol Succinate by Headspace Chromatography |
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| DANG Min-tuan,ZHANG Xue-ni.Research about the Detection to Residual Solvents that Remains in Metroprolol Succinate by Headspace Chromatography[J].Journal of Weinan Teachers College,2014(23):29-32. |
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| Authors: | DANG Min-tuan ZHANG Xue-ni |
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| Institution: | (School of Chemistry and Life Science, Weinan Normal University, Weinan 714099, China) |
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| Abstract: | A method is set up which detects residual solvents that remains in metroprolol succinate by headspace chromatogra-phy.External reference method and headspace auto-sample injection is used through nonpolarity flexibility quartz capillary chromato-graphic column and get a good effect.The linear range is from 0.001 to 0.300 mg/mL, the correlation coefficient R≥0.9990;stand-ard solution spiked levels from 0.001 to 0.300 mg/mL, the recovery rate is 90.73%to 104.80%, and the relative standard deviation is from 0.76%to 11.85%, the detection limit of method is 1.00μg/mL.This method of determining metroprolol succinate has a good reproducibility,nice quantitative and the operation is very easy. |
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| Keywords: | headspace gas chromatogram metroprolol succinate residual solvents |
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