Procedure and reliability of conditioned respiratory suppression |
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| Authors: | S Stefan Soltysik Nancy K Dess W Jeffrey Wilson John A Matochik Steve Berg |
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| Institution: | 1. MRRC, UCLA, NPI-58258, 90024, Los Angeles, CA
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| Abstract: | Changes in respiration amplitude, respiration rate, and heart rate in response to a conditioned signal for shock were measured concurrently in kittens and adult cats. The data were analyzed with respect to qualitative and quantitative variability across trials and subjects; correlation among measures; skewness; and kurtosis. Suppression of respiration amplitude was the most reliable response across trials and subjects, with increases in respiration rate second and heart rate by far the least reliable. Correlations between each pair of measures were moderate. Respiration-amplitude responses were negatively skewed, but this deviation from normality was moderate and consistent across subjects. The measurement of conditioned respiratory suppression is a viable addition or alternative to the conditioned emotional response procedure in studies of classically conditioned fear. |
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