| Enantioselective assay of S( )- and R(-)-propafenone in human urine by using RP-HPLC with pre-column chiral derivatization |
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| 作者姓名： | 吴永江 马明铭 曾苏 |
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| 作者单位： | College of Pharmaceutical Sciences，Zhejiang University，Hangzhou 310031，China，College of Pharmaceutical Sciences，Zhejiang University，Hangzhou 310031，China，College of Pharmaceutical Sciences，Zhejiang University，Hangzhou 310031，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China (No. 30225047) and by SRF for ROCS，SEM and Zhejiang Provincial Natural Science Foundation (No. RC97016)，China |
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| 摘 要： | INTRODUCTION Pharmacokinetic and pharmacodynamic dif-ferences involving stereoselective drug disposition are important for clinical evaluation of some chiral compounds that are rountinely administered in their racemic form (Zhou et al., 2002). Propafenone (PPF), a kind of Ic antiarrhythmics drug, is now marketed as racemate. The two enantiomers of PPF are equi- potent in terms of sodium channel-blocking activity, but the main side effect is the b-adreno recep-tor-blocking action of t…
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Enantioselective assay of S( )- and R(-)-propafenone in human urine by using RP-HPLC with pre-column chiral derivatization |
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| WU Yong-jiang,MA Ming-ming,ZENG Su.Enantioselective assay of S( )- and R(-)-propafenone in human urine by using RP-HPLC with pre-column chiral derivatization[J].Journal of Zhejiang University Science,2004(2). |
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| Authors: | WU Yong-jiang MA Ming-ming ZENG Su |
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| Abstract: | |
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| Keywords: | Enantioselective assay Propafenone Human urine Chiral derivatization High-performance liquid chroma-tography |
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