| 线粒体蛋白的转运方式和运输机制 |
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| 引用本文： | 周峰.线粒体蛋白的转运方式和运输机制[J].南京晓庄学院学报,2013(3):76-78. |
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| 作者姓名： | 周峰 |
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| 作者单位： | 南京晓庄学院生物化工与环境工程学院,江苏南京211171 |
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| 基金项目： | 江苏省自然科学基金青年项目（BK2012073）资助 |
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| 摘 要： | 线粒体是真核细胞中最重要的细胞器,其结构有4个区隔,外膜、内膜、膜间隙和基质.线粒体转运系统包括线粒体外膜易位子、内膜易位子、胞质中的可溶性因子、膜间隙和线粒体基质.文章重点介绍了线粒体前体蛋白向内膜、膜间隙和基质转运的运输机制及其转运体TOM40复合体、TIM23复合体、小Tim蛋白复合体和二硫键传递系统的结构和功能.
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| 关 键 词： | 线粒体 运输蛋白 分子伴侣 |
The Transportation Mode and Mechanism of Mitochondrial Protein |
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| ZHOU Feng.The Transportation Mode and Mechanism of Mitochondrial Protein[J].Journal of Nanjing Xiaozhuang College,2013(3):76-78. |
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| Authors: | ZHOU Feng |
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| Institution: | ZHOU Feng (School of Biochemical and Environmental Engineering, Nanjing Xiaozhuang University, Nanjing 211171, Jiangsu) |
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| Abstract: | Mitochondria are the most important organelles in eukaryotic cells. The spatial structure of mitochondria including four regions： outer membrane, inner membrane, intermembrane space and matrix. Mitochondrial trans- port system comprises the translocase of the outer and inner mitochondrial membrane, soluble factors of the cyto- plasm, intermembrane space and matrix. The transportation mechanism of mitochondrial precursor protein into in- ner membrane, intermembrane space and matrix are emphasized in this paper. The structure and function of trans- locators including TOM40 complex, TIM23 complex, small Tim proteins and the disulfide relay system are also dis- cussed in the present paper. |
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| Keywords: | mitochondria transportprotein chaperones |
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