Effects of chronic ethanol consumption in blood: A time dependent study on rat |
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| Authors: | Subir Kumar Das L Dhanya Sowmya Varadhan Sukhes Mukherjee D M Vasudevan |
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| Institution: | (1) Laboratory of Ecotoxicology, Department of Cellular and Environmental Biology, University of Perugia, 06123 Perugia, Italy;(2) C.Re.A.A. National Reference Centre for the Surveillance and Monitoring of Animal Feed, State Veterinary Institute, Torino, Italy;(3) Laboratory of Fish Pathology and Aquaculture, State Veterinary Institute, Torino, Italy |
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| Abstract: | Alcohol consumption and health outcomes are complex and multidimensional. Ethanol (1.6g / kg body weight/ day) exposure initially
affects liver function followed by renal function of 16–18 week-old male albino rats of Wistar strain weighing 200–220 g.
Chronic ethanol ingestion increased in thiobarbituric acid reactive substances level and glutathione s-transferase activity;
while decreased reduced gluatathione content and activities of catalase, glutathione peroxidase and glutathione reductase
in a time dependent manner in the hemolysate. Though superoxide dismutase activity increased initially might be due to adaptive
response, but decreased later. Elevation of serum nitrite level and transforming growth factor-b1 activity indicated that long-term ethanol consumption may cause hepatic fibrosis and can elicit pro-angiogenic factors. However,
no alteration in vascular endothelial growth factor-C activity indicated that ethanol consumption is not associated with lymphangiogenesis.
Therefore, we conclude that long-term ethanol-induced toxicity is linked to an oxidative stress, which may aggravate to fibrosis
and elevate pro-angiogenic factors, but not associated with lymphangiogenesis. |
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