Relationship between free iron and glycated hemoglobin in uncontrolled type 2 diabetes patients associated with complications |
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| Authors: | Jeevan K Shetty Mungli Prakash Mohammad S Ibrahim |
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| Institution: | (1) Department of Biochemistry, Kasturba Medical College, Manipal, 576104, Karnataka, India |
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| Abstract: | Free iron in serum has been found in several disease conditions including diabetes. In the present work, we studied the relationship
between free iron, fasting blood glucose (FBG) and glycated haemoglobin (HbA1c). Study was carried out on 50 type 2 diabetes cases under poor glycemic control associated with complications, 53 type 2
diabetes cases under good glycemic control and 40 healthy controls. We estimated free iron, both ferrous (Fe+2) and ferric (Fe+3) form, protein thiols, lipid hydroperoxides, FBG, HbA1c and serum ferritin levels in serum. There was a significant increase
in free iron in Fe+3 state (p <0.01), HbA1c (p<0.01), serum ferritin (p<0.01), lipid hydroperoxides (p<0.01) and significant decrease in protein thiols (<0.01) in diabetes
cases under poor glycemic control compared to diabetes cases under good glycemic control and healthy controls. Free iron correlated
positively with HbA1c (p<0.01). Poor glycemic control and increase in glycation of haemoglobin is contributing to the increase in free iron pool
which is known to increase oxidant generation. |
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| Keywords: | Free Iron Glycated Hemoglobin Ferritin |
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