| 不同频率有氧运动对大鼠离体肠系膜上动脉反应性的影响 |
| |
| 引用本文： | 刘晓东,石丽君,朱一力.不同频率有氧运动对大鼠离体肠系膜上动脉反应性的影响[J].北京体育大学学报,2012,35(4):44-48. |
| |
| 作者姓名： | 刘晓东 石丽君 朱一力 |
| |
| 作者单位： | 北京体育大学;首都体育学院 |
| |
| 基金项目： | 国家自然科学基金(31071033);北京市优秀人才培养资助(2010D009010000001);教育部高等学校博士学科点专项科研基金资助(20101112120001) |
| |
| 摘 要： | 目的:研究不同频率的有氧运动对大鼠离体肠系膜上动脉反应性的影响,并探讨其可能的平滑肌钾通道机制。方法:选用8周龄健康雄性Wistar大鼠18只,随机分成三组:安静对照组(SED)、低频有氧运动组(EX-3 d/周)和高频有氧运动组(EX-5 d/周)。运动方案为12周跑台运动,坡度0,°20 m/min,60 min/d。制备去内皮离体肠系膜上动脉血管环,用其测定各组对去甲肾上腺素(NE)、血管紧张素Ⅱ(AngⅡ)、非特异性K+通道阻断剂四乙胺(TEA)、大电导钙激活K+(BKCa)通道阻断剂Iberiotoxin(IbTX)以及BKCa通道开放剂NS1619的反应性变化。结果:各组血管对NE(10-9~3×10-5mol/L)有浓度依赖性收缩,有氧运动组张力增加幅度降低,并且EX-5 d/周张力增加幅度小于EX-3 d/周;AngⅡ(3×10-7mol/L)使血管张力增加,与SED相比,有氧运动组增加幅度明显减小,但EX-3 d/周和EX-5 d/周之间无显著性差异;TEA(3×10-3M)和IbTX(3×10-8M)均诱发血管张力增加,增加幅度EX-5 d/周EX-3 d/周SED;NE(10-5M)引起血管收缩达到最大时,给予NS1619(10-9~10-6M)可诱发血管呈浓度依赖性舒张,有氧运动组舒张反应显著增大,并且EX-5 d/周舒张幅度大于EX-3 d/周。结论:有氧运动可以诱发大鼠肠系膜上动脉的反应性改变,且呈频率依赖性,其中血管平滑肌BKCa通道起着重要作用。
|
| 关 键 词： | 有氧运动 肠系膜上动脉 血管张力 钾通道 |
| 收稿时间： | 2011/10/26 0:00:00 |
Effects of Aerobic Exercise in Different Frequencies on the Vascular Reactivity of the Superior Mesenteric Arteries |
| |
| LIU Xiao-dong,SHI Li-jun and ZHU Yi-li.Effects of Aerobic Exercise in Different Frequencies on the Vascular Reactivity of the Superior Mesenteric Arteries[J].Journal of Beijing Sport University,2012,35(4):44-48. |
| |
| Authors: | LIU Xiao-dong SHI Li-jun and ZHU Yi-li |
| |
| Institution: | 1.Beijing Sport University,Beijing 100084,China;2.Capital Institute of Physical Education,Beijing 100088,China) |
| |
| Abstract: | Objective: To study the effect of aerobic exercise in different frequencies on the vascular reactivity of the superior mesenteric arteries and to explore the possible mechanisms.Method: 18 male Wistar rats(8week) were randomly divided into three groups: sedentary control group(SED),low frequency training group(3days per week,EX-3d/week),high frequency training group(5days per week,EX-5d/week).The contractile responsiveness of the superior mesenteric arteries of all groups to norepinephrine(NE),angiotensinⅡ(AngⅡ),nonspecific K+ channel blocker tetraethylammonium(TEA),large conductance Ca2+-activated K+ channel(BKCa) blocker Iberiotoxin(IbTX) and BKCa opener NS1619 were examined.Result: NE(10-9~3×10-5M) caused a significantly increase of vascular tone in a concentration-dependent manner in all groups,while the increase amplitude was less in EX-5d/week group than in EX-3d/week group than in the SED group.AngⅡ(3×10-7M) could produce a sustained tension increase in all three groups,which was more significant in exercise groups than in SED group.TEA(3×10-3M) and IbTX(3×10-8M) could induce arterial tension increase,too.The maximal increase of vascular tone was EX-5d/week > EX-3d/week > SED.The dilation elicited by NS1619(10-9~10-6M) on NE-induced contraction was more significant in exercise groups(EX-3d/week and EX-5d/week) than in SED group.Conclusion: aerobic exercise training can change the vascular reactivity in superior mesenteric arteries in a frequency-dependent manner,in which BKCa channels of the vascular smooth muscle cells play an important role. |
| |
| Keywords: | aerobic exercise superior mesenteric artery vascular tone potassium channel |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《北京体育大学学报》浏览原始摘要信息 |
| 点击此处可从《北京体育大学学报》下载免费的PDF全文 |
|
