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Assessment of Oxidative Stress and Inflammatory Process in Patients of Multiple Myeloma |
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| Authors: | Moushumi Lodh Binita Goswami Nikhil Gupta Surajeet K Patra Alpana Saxena |
| Institution: | 1. Department of Clinical Biochemistry and Immunology, The Mission Hospital, Durgapur, West Bengal, India 2. Department of Biochemistry, Lady Hardinge Medical College & Associated Hospitals, New Delhi, India 3. Department of Surgery, Lady Hardinge Medical College, New Delhi, India 4. Department of Biochemistry, Maulana Azad Medical College & Associated Hospitals, New Delhi, India |
| Abstract: | Multiple myeloma is a disseminated malignancy of monoclonal plasma cells that accounts for 15 % of all hematological cancers. The present study was conducted to evaluate the role of inflammation and oxidant-antioxidant dynamics in the etiology of this disease. The study population comprised of 20 cases of multiple myeloma and 20 healthy controls. The parameters evaluated were serum malondialdehyde (MDA), superoxide dismutase (SOD) and ferritin levels. The serum MDA levels were 1.9 ± 0.96 nmol/ml in cases as compared to 0.98 ± 0.55 nmol/ml in the controls. Similarly, a statistically significant difference was noted in the SOD and ferritin levels between the cases and controls (93.2 ± 23.8 vs. 210.1 ± 190.5 U/ml and 285.8 ± 216.4 vs. 131.8 ± 30.1 ng/ml respectively). Our study highlights the imbalance in the oxidant-anti oxidant mechanism and the role of smoldering inflammation in the etiology of multiple myeloma. |
| Keywords: | Multiple myeloma Oxidative stress Thiobarbitone reactive substances (TBARS) Antioxidants Superoxide dismutase (SOD) Inflammation Ferritin |
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