Allergens/Antigens,Toxins and Polyketides of Important <Emphasis Type="Italic">Aspergillus</Emphasis> Species |
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| Authors: | Preetida J Bhetariya Taruna Madan Seemi Farhat Basir Anupam Varma Sarma P Usha |
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| Institution: | (1) Division of Plant Pathology, Indian Agricultural Research Institute, Pusa, New Delhi, 110012, India;(2) National Institute for Research in Reproductive Health (NIRRH), Parel, Mumbai, 400012, India;(3) Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India; |
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| Abstract: | The medical, agricultural and biotechnological importance of the primitive eukaryotic microorganisms, the Fungi was recognized
way back in 1920. Among various groups of fungi, the Aspergillus species are studied in great detail using advances in genomics and proteomics to unravel biological and molecular mechanisms
in these fungi. Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus, Aspergillus nidulans and Aspergillus terreus are some of the important species relevant to human, agricultural and biotechnological applications. The potential of Aspergillus species to produce highly diversified complex biomolecules such as multifunctional proteins (allergens, antigens, enzymes)
and polyketides is fascinating and demands greater insight into the understanding of these fungal species for application
to human health. Recently a regulator gene for secondary metabolites, LaeA has been identified. Gene mining based on LaeA
has facilitated new metabolites with antimicrobial activity such as emericellamides and antitumor activity such as terrequinone
A from A. nidulans. Immunoproteomic approach was reported for identification of few novel allergens for A. fumigatus. In this context, the review is focused on recent developments in allergens, antigens, structural and functional diversity
of the polyketide synthases that produce polyketides of pharmaceutical and biological importance. Possible antifungal drug
targets for development of effective antifungal drugs and new strategies for development of molecular diagnostics are considered. |
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| Keywords: | Aspergillus species Allergens Polyketides |
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