| The non-antibacterial effects and possible clinical applications of macrolide antibiotics |
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| 作者姓名： | TONG Shi-liang WANG Yuan-fiang GAO Wen-juan |
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| 作者单位： | Research Center |
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| 摘 要： | As a kind of fast bacteriostatic drugs, macrolides can block both the protein synthesis and the mRNA movement of bacteria via binding to 50S ribosome. Since erythromycin (EM), the 14-membered-ring macrolide was first used clinically as an antibiotic in 19…
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| 关 键 词： | 大环内酯 非抗菌效应 临床应用 抗生素 |
| 文章编号： | 1671-8224（2006）02-0115-04 |
| 收稿时间： | 2006-01-12 |
| 修稿时间： | 2006-03-08 |
The non-antibacterial effects and possible clinical applications of macrolide antibiotics |
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| TONG Shi-liang WANG Yuan-fiang GAO Wen-juan.The non-antibacterial effects and possible clinical applications of macrolide antibiotics[J].Journal of Chongqing University,2006,5(2):115-118. |
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| Authors: | TONG;Shi-liang;WANG;Yuan-fiang;GAO;Wen-juan |
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| Institution: | Research Center for Bio-inspired Materials Science and Engineering BIMSEC, College of Bioengineering,Chongqing University, Chongqing 400030, P. R. China |
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| Abstract: | As one group of the most widely used oral antibacterial drugs, macrolides have been clinically applied for more than 50 years because of their safety and efficacy. Recently, the non-antibacterial applications of macrolides are frequently reported, such as the therapy of malignant tumor, exudative pleurisy, pulmonary fibrosis, rheumatoid arthritis, bronchiectasis, asthma, gastrointestinal peristalsis disorders, and so on with new pharmacological effects, including reverse of tumor resistance, anti-chemical adherence, anti-fibrosis, and modulations of gastrointestinal motility as well as immune activity. The in-depth research of marcolides' non-antibiotic actions can not only extend the application fields of macrolides, but provide a new way to treat some refractory diseases. |
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| Keywords: | macrolides non-antibacterial effects clinical applications |
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