Antihyperglycemic,antihyperlipidemic and antioxidative potential of <Emphasis Type="Italic">Prosopis cineraria</Emphasis> bark |
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| Authors: | Nidhi Sharma Veena Garg Arpita Paul |
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| Institution: | (1) Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, 143 005, Punjab, India |
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| Abstract: | Alloxan administration in male Swiss albino mice, induced diabetes by increasing blood glucose concentration and reducing
hepatic glycogen content as compared to normal control group. Besides, serum lipid profile parameters such as total-cholesterol,
triglyceride, low-density lipoprotein and very low-density lipoprotein-cholesterol were also elevated, whereas, the level
of high-density lipoprotein-cholesterol was reduced significantly (P<0.05) in diabetic mice. Treatment of diabetic animals
with crude ethanolic extract of bark of Prosopis cineraria (P. cineraria) for 45 days, significantly lowered blood glucose
level, elevated hepatic glycogen content and maintained body weight and lipid-profile parameters towards near normal range.
Declined activity of antioxidant enzymes and concentration of non-enzymatic antioxidants were also normalized by drug treatment,
thereby reducing the oxidative damage in the tissues of diabetic animals and hence indicating the anti-diabetic and antioxidant
efficacy of the extract. |
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| Keywords: | |
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