| 适宜运动训练对反复心理应激大鼠海马脑源性神经营养因子的
影响 |
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| 引用本文： | 尹剑春.适宜运动训练对反复心理应激大鼠海马脑源性神经营养因子的
影响[J].天津体育学院学报,2009,24(1):75-78. |
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| 作者姓名： | 尹剑春 |
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| 作者单位： | 淮阴师范学院体育系,淮安,223001 |
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| 基金项目： | 淮阴师范学院青年优秀人才支持计划，淮阴师范学院青年教师基金 |
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| 摘 要： | 目的:探讨适宜运动训练对心理应激大鼠海马脑源性神经营养因子(BDNF)水平的影响.方法:对SD大鼠进行为期8周,每次60min的游泳运动训练,并在运动后期施加2周的心理应激,测定大鼠海马CA1区脑源性神经营养因子(BDNF)积分光密度、平均光密度、阳性物面积,面密度、阳性细胞数、数密度水平变化.结果:(1)经过2周心理应激后,心理应激绀大鼠海马CA1区脑源性神经营养因子(BDNF)积分光密度、平均光密度、阳性物面积,面密度、阳性细胞数、数密度水平显著低于对照组;(2)经过8周运动训练后,运动组人鼠海马CA1区脑源性神经营养因子(BDNF)积分光密度、平均光密度、阳性物面积,面密度、阳性细胞数、数密度水平显著高于对照组;同时运动+心理应激组大鼠海马CA1区脑源性神经营养因子(BDNF)积分光密度、平均光密度、阳性物面积,面密度、阳性细胞数、数密度水平显著高于应激组;结论:适宜运动训练可以降低心理应激反应程度,使大脑海马区BDNF水平提高,维持大脑海马区在应激状态下的生理功能稳定.
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| 关 键 词： | 运动 心理应激 海马 脑源性神经营养因子 |
The Effect of Adapted Exercise on Hippocampus Brain-Derived Neurotrophic Factor in Rats after Mental
Stress |
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| YIN Jianchun.The Effect of Adapted Exercise on Hippocampus Brain-Derived Neurotrophic Factor in Rats after Mental
Stress[J].Journal of Tianjin Institute of Physical Education,2009,24(1):75-78. |
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| Authors: | YIN Jianchun |
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| Institution: | Dept. of PE, Huaiyin Normal College, Huai'an 223001, China |
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| Abstract: | Objective: To explore the effect of exercise training on concentration of hippocampus brain-derived neurotrophic factor (BDNF) in mental stress rats. Methods: SD rats were conducted on exercise training with 60 min swimming for 8 weeks and exerted on mental stress for 2 weeks in the later stage of training. Concentration of points of optical density, average optical density, positive substance acreage, acreage density, positive cell, number density of BDNF
in hippocampus CA1 area were measured. Results: First, after 2 weeks mental stress, points of optical density, average optical density, positive substance acreage, acreage density, positive cell, number density of BDNF in hippocampus CA1 area was significant lower than that in control group. Second, after 8 weeks training, points of optical density, average optical density, positive substance acreage, acreage density, positive cell, number density of BDNF in hippocampus CA1 area were significant higher than that in control group, points of optical density, average optical density, positive substance acreage, acreage density, positive cell, number density of BDNF in hippocampus CA1 area training plus mental stress were higher than that in mental stress group. Conclusion: Adapted training can decrease the intensity of mental stress and increase BDNF in hippocampus, and maintain the stabilization of brain function under mental stress state. |
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| Keywords: | exercise mental stress hippocampus BDNF |
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