A microfluidic model to study fluid dynamics of mucus plug rupture in small lung airways |
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| Authors: | Yingying Hu Shiyao Bian John Grotberg Marcel Filoche Joshua White Shuichi Takayama James B Grotberg |
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| Institution: | 1School of Electric Power Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China;2Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 48109, USA;3The University of Illinois at Chicago, Chicago, Illinois 60607, USA;4Physique de la Matière Condensée, Ecole Polytechnique, CNRS, 91128 Palaiseau, France |
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| Abstract: | Fluid dynamics of mucus plug rupture is important to understand mucus clearance in lung airways and potential effects of mucus plug rupture on epithelial cells at lung airway walls. We established a microfluidic model to study mucus plug rupture in a collapsed airway of the 12th generation. Mucus plugs were simulated using Carbopol 940 (C940) gels at concentrations of 0.15%, 0.2%, 0.25%, and 0.3%, which have non-Newtonian properties close to healthy and diseased lung mucus. The airway was modeled with a polydimethylsiloxane microfluidic channel. Plug motion was driven by pressurized air. Global strain rates and shear stress were defined to quantitatively describe plug deformation and rupture. Results show that a plug needs to overcome yield stress before deformation and rupture. The plug takes relatively long time to yield at the high Bingham number. Plug length shortening is the more significant deformation than shearing at gel concentration higher than 0.15%. Although strain rates increase dramatically at rupture, the transient shear stress drops due to the shear-thinning effect of the C940 gels. Dimensionless time-averaged shear stress, Txy, linearly increases from 3.7 to 5.6 times the Bingham number as the Bingham number varies from 0.018 to 0.1. The dimensionless time-averaged shear rate simply equals to Txy/2. In dimension, shear stress magnitude is about one order lower than the pressure drop, and one order higher than yield stress. Mucus with high yield stress leads to high shear stress, and therefore would be more likely to cause epithelial cell damage. Crackling sounds produced with plug rupture might be more detectable for gels with higher concentration. |
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