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| 运动心脏重塑的发生与转归 | |
| 引用本文： | 常芸,林福美,陈小同,罗安明.运动心脏重塑的发生与转归[J].体育科学,2000,20(5):46-50. |
| 作者姓名： | 常芸 林福美 陈小同 罗安明 |
| 作者单位： | 1. 国家体育总局,体育科学研究所,北京,100061 2. 北京医科大学,内分泌研究所,北京,100083 3. 成都体育学院,四川,成都,610041 |
| 摘 要： | 为了进一步探讨运动心脏结构与功能的发生、转归及其与病理心脏的本质差异，作者通过动物实验模拟运动心脏，观察了经过12周耐力训练及完全停止运动训练8周后心脏重量和超微结构的变化，并应用激光扫描共聚焦显微镜与新一代钙荧光指示剂Fluo—3／AM负载方法对心肌活细胞内具有生物活性的游离钙的动态变化进行了研究。结果表明，运动心脏超微结构和胞内钙产生了良好的适应性改变，心肌收缩时收缩结构钙可获得量增多，构成运动心脏心肌收缩性、氧化代谢及自分泌功能增强的重要细胞机制。完全停训后，运动心肌细胞内游离钙，心房特殊囊粒，心肌线粒体及毛细血管结构适应性改变的消退证实运动心脏结构与功能改变具有可恢复性，区别于病理心脏。 |
| 关 键 词： | 停止训练 运动心脏 细胞内游离钙 心肌显微形态计量 激光扫描共聚焦显饭镜 |
| 修稿时间： | 2000-01-28 |
The Structural Development and Reversibility in Exercise Induced Heart Remodeling |
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| CHANG Yun,et al.The Structural Development and Reversibility in Exercise Induced Heart Remodeling[J].China Sport Science,2000,20(5):46-50. | |
| Authors: | CHANG Yun |
| Abstract: | In order to investigate the development and prognosis of exercise induced heart remodeling, the changes of the intracellular Ca 2 ] were determined in single isolated ventricular myocyte under the laser scanning confocal microscopy; the myocardial ultrastructures were analyzed by computer image system, 80 male SD rats were randomly divided into endurance running group, deconditioning group and their sedentary controls. The results showed that there was a intracellular calcium homeostasis in athletic heart and the calcium supplement to myocardial contractile elements was increased while heart contraction. The myocardial ultrastructures produced good adaptation. Those changes were important mechanism for improved heart contractility, metabolism and self endocrine. And the elevated myocardial Ca 2 ]i peak level might be a signal linking between cardiac hormons and exercise induced cardiac hypertrophy. Also, the changes of myocardialCa 2 ]i and myocardial ultrastructures were reversible while deconditioning. |
| Keywords: | deconditioning athletic heart myocardial morphometry intracellular free calcium laser scanning confocal microscopy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |