Effect of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines in humans: A pilot study |
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| Authors: | B Raghu P Venkatesan |
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| Institution: | (1) Faculty of Medicine, Asian Institute of Medicine, Science and Technology, 00080 Sungai, Petani, Malaysia;(2) Department of Bio-Statistics, Tuberculosis Research Center, Chennai, 600031, India;(3) X-6, Anna Nagar, Chennai, 600040, India |
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| Abstract: | This study was undertaken to evaluate the effects of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines
in humans. Twenty adult healthy subjects were supplemented with 1g/day fish oil concentrate capsules for 2 weeks. Fasting
blood samples were taken at baseline and again after 2 week intervention. Fish oil supplementation significantly lowered fasting
serum concentrations of total cholesterol, triacylglycerol, very low density lipoprotein and low density lipoprotein (P <
0.01). Also high density lipoprotein increased significantly compared with baseline value (P < 0.01). Fish oil did not significantly
altere the fasting blood glucose concentration but significantly reduced the serum cytokines (P < 0.001). This study demonstrated
that eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) supplementation altered serum lipids, lipoprotein and cytokine
concentrations in normal human subjects even at the small dose of 660 mg of EPA plus DHA per day. It appears that EPA plus
DHA can be a safe and perhaps beneficial supplement to inflammatory diseases. |
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| Keywords: | n-3 fatty acid Blood Glucose Lipid profile Cytokines |
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