| Synthesis of 3-Alkyl-5-Benzylidene-2,4-Thiazolidinedione Under Microwave Irradiation |
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| 作者姓名： | 李筱芳 冯亚青 张卫红 王冬慧 |
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| 作者单位： | School of Chemical Engineering and Technology，School of Chemical Engineering and Technology，School of Chemical Engineering and Technology，School of Chemical Engineering and Technology State Key Laboratory of C 1 Chemical Techniques，Tianjin University，Tianjin 300072，China，State Key Laboratory of C 1 Chemical Techniques，Tianjin University，Tianjin 300072，China，State Key Laboratory of C 1 Chemical Techniques，Tianjin University，Tianjin 300072，China，State Key Laboratory of C 1 Chemical Techniques，Tianjin University，Tianjin 300072，China |
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| 摘 要： | 5 Benzylidene 2 ,4 thiazolidinedionederivativesarere portedtohavediversebiologicalactivities1] suchasantidia betic2 ] ,antibacterial3] andanticonvulsant4 ] activities .Forexample,pioglitazoneandrosiglitazonehavebeenlaunchedrecentlyfortypeⅡdiabetesmellitus2 ] .Theyalsocanbeusedforthetreatmentofpsoriasis5] andobesity6 ] . Thegeneralmethodsforthesynthesisof 5 benzylidene 2 ,4 thiazolidinedionewasKnoevenagelcondensationof 2 ,4 thiazolidinedionewitharomaticaldehyde . Inrecentyear…
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Synthesis of 3-Alkyl-5-Benzylidene-2,4-Thiazolidinedione Under Microwave Irradiation |
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| LI Xiao-fang,FENG Ya-qing,ZHANG Wei-hong,WANG Dong-hui.Synthesis of 3-Alkyl-5-Benzylidene-2,4-Thiazolidinedione Under Microwave Irradiation[J].Transactions of Tianjin University,2003,9(3). |
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| Authors: | LI Xiao-fang FENG Ya-qing ZHANG Wei-hong WANG Dong-hui |
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| Abstract: | Microwave irradiation of aromatic aldehyde and 2,4-thiazolidinedione provides a fast and high-yield access to 5-benzylidene-2,4-thiazolidinedione. Seven 3-alkyl-5-benzylidene-2,4-thiazolidinedione compounds were produced with high yield by reacting 5-benzylidene-2,4-thiazolidinedione with different alkylating agents under microwave irradiation. |
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| Keywords: | benzylidene-2 4-thiazolidinedione microwave irradiation N-alkylation synthesis |
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