| Study on the Crystallization Mechanism of Spectinomycin Dihydrochloride |
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| 作者姓名： | 鲍颖 王静康 王永莉 戚振 王宏斌 |
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| 作者单位： | School of Chemical Engineering and Technology，School of Chemical Engineering and Technology，School of Chemical Engineering and Technology，Shandong Lukang Pharmaceutical Co.Ltd.，Shandong Lukang Pharmaceutical Co.Ltd. Tianjin University，Tianjin 300072，China，Tianjin University，Tianjin 300072，China，Tianjin University，Tianjin 300072，China，Jining 272121，Shandong Province，China，Jining 272121，Shandong Province，China |
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| 摘 要： | Dilutionisonekindofcrystallizationsthatiswidelyusedintheproductionofpharmaceuticals ,especiallyantibi otics.Dilutionhasmanyadvantagessuchashigherthrough putsbypreparingveryconcentratedinitialsolutions,loweroperatingtemperatureforheat labilesubstancesandbetterpu rificationasthemotherliquorretainsundesiredimpurities1] .Oneofthecharacteristicsofdilutionisthatthesolventcom positionvarysastheprocessproceeds.Thesolventcomposi tionhasinfluenceonnotonlythenucleationratebutalsotherelativegrowthrateofe…
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Study on the Crystallization Mechanism of Spectinomycin Dihydrochloride |
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| BAO Ying,WANG Jing-kang,WANG Yong-li,QI Zhen,WANG Hong-bin.Study on the Crystallization Mechanism of Spectinomycin Dihydrochloride[J].Transactions of Tianjin University,2003,9(3). |
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| Authors: | BAO Ying WANG Jing-kang WANG Yong-li QI Zhen WANG Hong-bin |
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| Institution: | 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
2. Shandong Lukang Pharmaceutical Co.Ltd., Jining 272121, Shandong Province, China |
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| Abstract: | The growth mechanism of spectinomycin dihydrochloride crystal in pure water and acetone-water mixture at different temperatures has been studied by induction period measurement. The induction period was measured visually. The solid-liquid interfacial tension was determined on the basis of classical homogenous nucleation theory and the surface entropy factor was calculated. It was shown that the interfacial tension and surface entropy factor increased with the increase of acetone concentration and the decrease of temperature. It was demonstrated that the growth mechanism of spectinomycin dihydrochloride crystal was controlled by birth and spread growth in pure water or in acetone-water mixture at high temperatures and turned from birth and spread growth to spiral growth with the increase of acetone concentration in acetone-water mixture at low temperatures. |
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| Keywords: | induction period interfacial tension surface entropy factor nucleation growth mechanism |
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