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Effect of radiotherapy on serum sialic acid level in carcinoma cervix |
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| Authors: | H R Mali M L B Bhatt M P Singh S M Natu J P Gupta |
| Institution: | 1. Department of Radiotherapy, K.G. Medical College, 226 003, Lucknow 2. Department of Pathology, K.G. Medical College, 226 003, Lucknow 3. Mahila Aspatal, 226 003, Lucknow |
| Abstract: | Serum sialic acid levels were determined in 66 patients of carcinoma cervix and 25 control women matched for age. Mean sialic acid level was significantly elevated (p<0.001) in cancer cervix patients as compared to controls. Patients were treated with 50–65 Gy of radiation in 5–6.5 weeks. Post-therapy levels were again determined. Radiotherapy caused decline in serum sialic acid level in all the patients except one. Mean post-therapy level was significantly lower as compared to pretreatment level (p<0.001). It was also observed that fall in sialic acid level was significantly higher (p<0.05) in early stage patients as compared to late stage. No relationship was observed in the dose of radiation and fall in serum sialic acid level. A significantly higher fall in serum sialic acid level was observed in patients having complete clinical response as compared to partial or nonresponders to radiation treatment (p<0.001). |
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