| 缺血预处理对大鼠脑缺血再灌注NO代谢的影响 |
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| 引用本文： | 薛茜,邹玉安,韩敏.缺血预处理对大鼠脑缺血再灌注NO代谢的影响[J].河北北方学院学报(医学版),2005,22(2):15-17. |
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| 作者姓名： | 薛茜 邹玉安 韩敏 |
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| 作者单位： | 1. 河北北方学院附属第一医院神经内科,河北,张家口,075000
2. 河北北方学院病理生理教研室,河北,张家口,075000 |
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| 摘 要： | 目的:利用Bannisterr建立的颈动脉引流法制作大鼠急性脑缺血再灌注模型研究缺血预处理对一氧化氮(NO)代谢的影响.方法:将18只大鼠分为模型组、缺血预处理(IPC)组和对照组,观察血清和脑皮质中NO的变化.结果:模型组大鼠脑内及血清NO水平升高,较对照组有统计学差异(P＜0.01).IPC组和模型组相比血浆中NO含量增加(P＜0.01),脑皮质中NO含量降低(P＜0.01).结论:缺血预处理可通过抗自由基功能影响NO代谢并保护神经细胞.
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| 关 键 词： | 缺血预处理 缺血再灌注 自由基 一氧化氮 |
| 文章编号： | 1673-1484(2005)02-0015-03 |
Study on Effect of Ischemic Preconditioning on NO Metabolism of Brain Ischemia Reperfusion Model of Rat |
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| XUE Qian,ZOU Yu-an,HAN Min.Study on Effect of Ischemic Preconditioning on NO Metabolism of Brain Ischemia Reperfusion Model of Rat[J].Journal of Hebei North University:Medical Edition,2005,22(2):15-17. |
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| Authors: | XUE Qian ZOU Yu-an HAN Min |
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| Abstract: | Objective:To study the effect of NO metabolism and mechanism of ischemic preconditioning in the acute ischemia reperfusion model of rat brain with bilateral carotide blocking. Methods: 18 rats were divided into model group, ischemic preconditioning group(IPC) and control group. The changes in metabolism of NO in the brain tissue and plasma were observed. Results: Compared with the control group, the concentration of NO in the model group was in the brain tissue and plasma increased significantly . Compared with the model group, NO concentration in the plasma increased in the IPC group and decreased in the brain tissue. Conclusion: The protective action of preconditioning is related to the scavenging of oxygen free radicals to decrease NO. |
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| Keywords: | ischemic preconditioning ischemia-reperfusion free radical nitric oxide |
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