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| p53基因蛋白在食道正常上皮及增生、癌变后表达的观察 | |
| 引用本文： | 马春梅,张世棋,王德仲,王金光,刘振显,薄爱华,张晓丽.p53基因蛋白在食道正常上皮及增生、癌变后表达的观察[J].河北北方学院学报(医学版),2002,19(2):59-60. |
| 作者姓名： | 马春梅 张世棋 王德仲 王金光 刘振显 薄爱华 张晓丽 |
| 作者单位： | 1. 张家口医学院电镜室大学生科协,075000 2. 张家口医学院一附院外科,075000 3. 张家口医学院电镜室,075000 |
| 摘 要： | 目的 :探讨p5 3蛋白在食管癌组织发生中表达的意义。方法 :应用免疫组织化学技术检测 72例食管鳞状上皮癌 ,19例增生鳞状上皮及 17例正常食道鳞状上皮中 p5 3蛋白的表达。结果 :p5 3在食管癌组织中的阳性率为 4 7.95 % (35 / 72 ) ,在增生鳞状上皮中的阳性率为 36 .84 % (7/ 19) ,在正常食道鳞状上皮中的阳性率为 5 .88% (1/ 17) ,正常组与增生组和癌变组比较均有显著性差异 (P <0 .0 5 )。p5 3蛋白与癌的分化程度、淋巴结有无转移和浸润深度等指标均无明显关系。结论 :p5 3蛋白与食管癌的发生、发展有关。 |
| 关 键 词： | 食管癌 免疫组织化学 p53蛋白 |
| 文章编号： | 1005-8796(2002)02-059-02 |
Expression of p53 Protein in esophageal Carcinorma |
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| Ma Chunmei,Zhang Shiqi,Wang Dezhong,et al..Expression of p53 Protein in esophageal Carcinorma[J].Journal of Hebei North University:Medical Edition,2002,19(2):59-60. | |
| Authors: | Ma Chunmei Zhang Shiqi Wang Dezhong |
| Institution: | Ma Chunmei,Zhang Shiqi,Wang Dezhong,et al. Zhangjiakou Medical College,zhangjiakou,075000,China |
| Abstract: | Objective:To strdy the significance of the expression of p53 protein in esophagus Carcinoma.Methods:Immunohistochemistry is used to detect the expression of p53 in carcinoma of the esophageal(n=72) the hyperplastic squamous cell (n=19) and the normal esophageal squamous cell(n=17).Results: The positive rate of p53 protein in the normal esophageal squamous cell ?the hyperplastic squamous cell and carcinoma was 5.88%?36.84% and 47.95%, rspectively , the difference was significant (P<0.05).Conclusions: p53 protein is related with occurring and developing of carcinoma of the esophagus. |
| Keywords: | esophageal carcinoma Immunohistochemistry p53 protein |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |