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Antidyslipidemic and Antioxidant Activities of Hibiscus rosa sinensis Root Extract in Alloxan Induced Diabetic Rats |
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| Authors: | Vishnu Kumar Farzana Mahdi Ashok Kumar Khanna Ranjana Singh Ramesh Chander Jitendra Kumar Saxena Abbas Ali Mahdi Raj Kumar Singh |
| Institution: | 1. Department of Biochemistry, Era’s Lucknow Medical College & Hospital, Sarfarazganj, Hardoi Road, Lucknow, 226003, India 2. Division of Biochemistry, Central Drug Research Institute, Lucknow, India 3. Department of Biochemistry, C.S.M. Medical University, Lucknow, India 4. Department of Biochemistry, Shri Guru Ram Rai Institute of Medical & Health Sciences, Dehradun, India |
| Abstract: | The antidyslipidemic activity of Hibiscus rosa sinensis (Malvaceae) root extract has been studied in alloxan induced diabetic rats. In this model, oral administration of root extract (500 mg/kg bw. p.o.) for 15 days resulted in significant decreased in the levels of blood glucose, plasma lipids and reactivated post heparin lipoprotein lipase activity in alloxan induced diabetic rats. Furthermore, the root extract (50–500 μg) when tested for its antioxidant activity, inhibited the generation of super oxide anions and hydroxyl radicals, in both enzymic and non enzymic systems in vitro. The results of the present study demonstrated antidyslipidemic and antioxidant activities in root extract of H. rosa sinensis which could be used in prevention of diabetic-dyslipidemia and related complications. |
| Keywords: | Hibiscus rosa sinensis Anti-dyslipidemic agent Natural antioxidants Post heparin lipolytic activity Alloxan induced-diabetes Hypoglycemic agent |
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