Interdisciplinary therapy changes superoxide dismutase activity and adiponectin in obese adolescents: a randomised controlled trial |
| |
| Authors: | João Elias Dias Nunes Heitor Santos Cunha Zulmária Rezende Freitas Ana Maria Caixeta Nogueira Ana Raimunda Dâmaso Foued Salmen Espindola |
| |
| Institution: | 1. Federal University of Uberlandia, Uberlandia, Braziljoaoelias@faefi.ufu.br;3. Federal University of Uberlandia, Uberlandia, Brazil;4. Federal University of S?o Paulo, S?o Paulo, Brazil |
| |
| Abstract: | The objective of this study is to evaluate the effect of interdisciplinary therapy in the parameters of the oxidative stress and the anti-inflammatory responses of obese adolescents. We selected 57 participants, who were randomly divided into 2 groups: interdisciplinary therapy group and a control group. After 6 months of intervention, 17 participants of the interdisciplinary therapy group and 8 of the control group returned for re-evaluation. The interdisciplinary therapy group participated in a treatment with 4 weekly sessions of exercise, a weekly group therapy session and a weekly nutritional education session. Blood parameters of oxidative stress and anti-inflammatory response were evaluated. The results demonstrated that there were significant increases in the interdisciplinary therapy group for superoxide dismutase activity (6.56 ± 3.22 to 11.40 ± 7.49) and ferric-reducing antioxidant potential concentration (532.91 ± 106.48 to 573.25 ± 112.57), although adiponectin levels did not reduce (40.9 ± 29.34 to 49.05 ± 41.22). A significant decrease in nitrite levels was also found (14.23 ± 8.48 to 11.45 ± 6.05). In the control group, significant reduction was found in adiponectin (31.56 ± 18.88 to 18.01 ± 11.66). This study suggests that interdisciplinary therapy for 6 months was effective in improving the anti-inflammatory responses and the antioxidant defences in obese adolescents. |
| |
| Keywords: | Treatment outcome oxidative stress inflammation obesity adolescent adiponectin superoxide dismutase |
|
|
