| ABCA1基因M883I多态性与子痫前期发病的关联 |
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| 引用本文： | 刘黎星,闵羡蕙,张敏.ABCA1基因M883I多态性与子痫前期发病的关联[J].莆田学院学报,2015(2):13-17,70. |
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| 作者姓名： | 刘黎星 闵羡蕙 张敏 |
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| 作者单位： | 莆田学院基础医学院;解放军南京军区福州总医院第一附属医院妇产科 |
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| 基金项目： | 福建省教育厅基金资助项目(JK2013045) |
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| 摘 要： | 探讨ABCA1基因M883I多态性在福建汉族女性中的分布特点及其与子痫前期患者体内ABCA1蛋白表达、血脂水平的关联性。研究对象400例,包括正常对照组、子痫前期病例组各200例。采用PCR-RFLP法测定ABCA1基因外显子区M883I在病例组及对照组中的多态性分布特点,ELISA法测定ABCA1蛋白表达水平,并检测血脂水平。结果:ABCA1基因M883I多态性对子痫前期的发病率无显著影响,但子痫前期患者中MI+II基因型血清ABCA1蛋白浓度及外周血HDL-C、Apo A1均明显高于MM基因型,差异显著(P<0.05)。结果表明:ABCA1基因M883I在福建汉族女性中,I等位基因可提高血清中ABCA1蛋白的表达,使血液中HDL-C及Apo A1水平升高,从而降低了子痫前期合并血脂代谢紊乱的风险性。
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| 关 键 词： | ABCA1基因 M883I 单核苷酸多态性 子痫前期 脂代谢 |
M883I Polymorphism of ABCA1 Gene is Associated with the Pathogenesis of Preeclampsia |
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| LIU Li-xing;MIN Xian-hui;ZHANG Min.M883I Polymorphism of ABCA1 Gene is Associated with the Pathogenesis of Preeclampsia[J].journal of putian university,2015(2):13-17,70. |
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| Authors: | LIU Li-xing;MIN Xian-hui;ZHANG Min |
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| Institution: | LIU Li-xing;MIN Xian-hui;ZHANG Min;College of Basic Medical Science, Putian University;Department of Obstetrics and Gynecology, First Hospital Affiliated to Fuzhou General Hospital of Nanjing Military Command of PLA; |
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