| RhoC和MMP-9蛋白在结直肠癌中的表达及意义 |
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| 引用本文： | 陈小兰.RhoC和MMP-9蛋白在结直肠癌中的表达及意义[J].莆田学院学报,2009,16(2). |
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| 作者姓名： | 陈小兰 |
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| 作者单位： | 莆田学院基础医学部,福建,莆田,351100 |
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| 摘 要： | 探讨RhoC和基质金属蛋白酶-9(MMP-9)蛋白在结直肠癌发生发展中的作用。选取新鲜结直肠癌标本作为实验组,正常新鲜结肠粘膜组织作为对照组,应用流式细胞术分别检测RhoC和MMP-9的表达,检测其在不同临床病理特征之间的关系。结果表明,RhoC和MMP-9在结直肠癌组织中高表达(P<0.05),且其表达均与Dukes分期、浸润深度及炎细胞浸润相关(P<0.05),MMP-9的表达与结直肠癌的淋巴结转移密切相关(P<0.05),RhoC和MMP-9在结直肠癌中的表达呈正相关(r=0.3430,P=0.0420)。流式细胞术联合检测RhoC和MMP-9蛋白的表达有望成为判断预后的重要指标。
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| 关 键 词： | 结直肠癌 RhoC MMP-9 预后 流式细胞术 |
The Expressions and Significance of RhoC and MMP-9 in Colorectal Carcinoma |
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| CHEN Xiao-lan.The Expressions and Significance of RhoC and MMP-9 in Colorectal Carcinoma[J].journal of putian university,2009,16(2). |
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| Authors: | CHEN Xiao-lan |
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| Institution: | General Medicine Department;Putian University;Putian Fujian 351100;China |
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| Abstract: | The study chooses colorectal carcinoma as experimental group and colonic mucosa tissues as control group to observe the expressions of RhoC and MMP-9 in different pathological character by Flow Cytometry(FCM).According to the result,their expressions are higher in the colorectal carinoma(P<0.05),which are correlated with Dukes stage,invasive depth and inflammatory cell infiltration(P<0.05).And the expression of MMP-9 is associated with lymph node metastasis(P <0.05).There is also a positive correlationship ... |
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| Keywords: | RhoC MMP-9 |
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