| 缺电子Rh-BINAP催化剂催化氢化富电性底物的机理研究 |
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| 作者姓名： | 黄碧玉 吴海臣 杨镜奎 |
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| 作者单位： | 1. 中国科学院研究生院化学与化学工程学院, 北京 100049;2. 中国科学院高能物理研究所, 北京 100049 |
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| 基金项目： | Supported by the Project of the National Natural Science Foundation of China(20972159) and the President Fund of GUCAS |
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| 摘 要： | 合成了4种富电性的脱氢α-氨基酸衍生物,将缺电子催化剂Rh-3,5-CF3-(R)-BINAP用于这几种底物的不对称氢化反应中. 讨论了底物上取代基及空间位阻对对映选择性的影响.
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| 关 键 词： | 富电性底物 缺电子催化剂 不对称氢化 机理 |
| 收稿时间： | 2011-05-06 |
| 修稿时间： | 2011-05-12 |
Mechanistic study on hydrogenation of electron-rich substrates with electron-deficient Rh-BINAP catalyst |
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| Authors: | HUANG Bi-Yu WU Hai-Chen YANG Jing-Kui |
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| Institution: | 1. College of Chemistry and Chemical Engineering, Graduate University, Chinese Academy of Sciences, Beijing 100049, China;2. Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Four electron-rich α-acetamidocinnamic acid derivatives were prepared and used as substrates in the asymmetric hydrogenation catalyzed by electron-deficient Rh-3,5-CF3-(R)-BINAP. Influence of the electronic properties of substituted groups in the substrates and their steric hindrance on the enantioselectivity of the product were discussed. |
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| Keywords: | electron-rich substrates electron-deficient Rh-BINAP catalyst asymmetric hydrogenation mechanism |
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