| 归芪五味消毒饮联合抗生素预防关节置换术后感染的临床观察 |
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| 引用本文： | 黄平,余南征,杨林,周熙俊,蔡乐乐,邬瑶,李鸿.归芪五味消毒饮联合抗生素预防关节置换术后感染的临床观察[J].宜春学院学报,2021(3):63-65,68. |
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| 作者姓名： | 黄平 余南征 杨林 周熙俊 蔡乐乐 邬瑶 李鸿 |
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| 作者单位： | 江西省丰城市中医院 |
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| 摘 要： | 目的:探讨归芪五味消毒饮联合抗生素预防关节置换术后感染的临床疗效。方法:2015年10月至2020年10月收治200例关节置换患者,其中全髋关节置换50例,人工股骨头置换80例,全膝关节置换40例,膝关节单髁置换30例,每种病例随机分成2组,一组为观察组,另一组为对照组。所有患者常规应用抗生素,同时观察组于术后第1d开始口服归芪五味消毒饮,每天1剂,连用5d。分别于手术前、术后1、5d抽静脉测定C反应蛋白(CRP)、血测白细胞数量(WBC)、红细胞沉降率(ESR)。同时随访观察患者的切口愈合情况。结果:观察组和对照组手术前和手术后第1d后的CRP、WBC计数、ESR比较,差异均无统计学意义。术后1d的CRP、WBC计数、ESR均高于术前和术后5d(对照表1、2、3)。术后第5天两组之间的CRP、WBC计数、ESR比较,差异均有统计学意义。术后观察组均未发生感染,切口均愈合良好,对照组4例切口浅表感染,伤口延迟愈合。观察组切口愈合时间(13±3)d,对照组切口愈合时间(16±4)d。结论:归芪五味消毒饮联合抗生素可明显改善血液炎性指标,预防关节置换术后感染。
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| 关 键 词： | 归芪五味消毒饮 抗菌药 感染 关节置换 围手术期 |
Clinical Observation of Preventing Postoperative Infection After Joint Replacement with Gui Qi Wuwei Xiaodu Yin Combined with Antibiotics |
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| HUANG Ping,YU Nan-zheng,YANG Lin,ZHOU Xi-jun,CAI Le-le,WU Yao,LI Hong.Clinical Observation of Preventing Postoperative Infection After Joint Replacement with Gui Qi Wuwei Xiaodu Yin Combined with Antibiotics[J].Journal of Yichun University,2021(3):63-65,68. |
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| Authors: | HUANG Ping YU Nan-zheng YANG Lin ZHOU Xi-jun CAI Le-le WU Yao LI Hong |
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| Institution: | (Fengchen Hospital of TCM,Fengchen 331100,China) |
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| Abstract: | Objective:To explore the clinical curative effects of Gui Qi Wuwei Xiaodu Yin(GQWWXDY)combined with antibiotics in preventing postoperative infection after joint replacement.Methods:Two hundred patients who need joint replacement were recruited from Oct.2015 to Oct.2020.There were 50 cases of total hip arthroplasty(THA),80 cases of femoral head arthroplasty(HA),40 cases of total knee arthroplasty(TKA)and 30 cased of unicompartment knee arthroplasty(UKA),each case was randomly divided into two groups,one group is observation group and the other group is control group.All patients were treated with conventional antibiotics,meanwhile,observation group were treated with oral application of GQWWXDY from the 1 st day after surgery,one dose a day for consecutive 5 days.The blood was drawn from vein before the surgery and at 1 and 5 days after the surgery respectively.The number white blood cells(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)in the venous blood.At the same time,follow-up to observe the wound healing of the patients.Results:There was no statistical difference in the number of CRP,WBC,EST,between different time points of pre-surgery and postoperative day 1 for patients with the observation group and the control group.The number of CRP,WBC and ESR were higher at postoperative day 1 compared to pre-surgery and postoperative day 5.(Compare Table 1,Table 2,Table 3).There was statistical difference in the number of ESR,CRP,WBC at the time point of postoperative day 5 for patients with observation group and the other group as control group.No infections were found in observation group after surgery and all incisions healed well.In the control group,4 patients had superficial wound infection and delay wound healing.The incision healing times for patients with observation group were 13±3 days.The incision healing times for patients with control group were 16±4 days.Conclusion:The application of GQWWXDY combined with antibiotic can obviously improve blood inflammatory indexes and prevent postoperative infection in patients with joint replacement. |
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| Keywords: | Gui Qi Wuwei Xiaodu Yin anti-bacterial agents infection joint replacement perioperative period |
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