Effects of short-term hormone replacement on atherogenic indices in Indian postmenopausal women |
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| Authors: | Sarika Arora Anju Jain R Chitra |
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| Institution: | (1) Department of Biochemistry, Lady Hardinge Medical College & Smt. Sucheta Kriplani Hospital, 110 001 New Delhi, India;(2) Department of Gynecology and Obstetrics, Lady Hardinge Medical College and associated Smt. Sucheta Kriplani Hospital, New Delhi, India |
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| Abstract: | Indian ethnicity by itself is a strong risk factor for development of CAD in Indian postmenopausal women due to lower HDL
levels as compared to Whites and women of oriental origin. We evaluated and compared the short-term effects of menopause,
estrogen replacement therapy and combined estrogen and progestin replacement therapy on various atherogenic indices. 40 postmenopausal
women, both surgical and natural (20 each) were selected. 10 surgical postmenopausal women were given 0.625 mg conjugated
estrogens daily for 6 months and 10 natural postmenopausal women were given 0.625 mg conjugated estrogen with 2.5 mg medroxyprogesterone
acetate daily. 20 women were included in the control group and given placebo. Fasting venous blood samples were analyzed for
extended lipid profile and calculated atherogenic indices before starting the therapy and after 1,3 and 6 months. LDL and
Apolipoprotein B increased (p<0.05) and those of Apolipoprotein A1 and HDL decreased in the control groups. In both the study
groups levels of serum cholesterol and LDL decreased (p<0.05) and those of HDL and Apolipoprotein A1 increased (p<0.01). LDL/HDL,
Apo B/ApoA1, Total Cholesterol/HDL decreased significantly (p<0.05) in both the study groups compared to the control groups.
The effect of estrogen alone was more significant as compared to combination therapy. Log Triglycerides (TG)/HDL ratio showed
a decrease in women on estrogen alone but the difference was not significant. Our study confirms that short term HRT has a
favorable effect on atherogenic indices in Indian postmenopausal women. |
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| Keywords: | LDL/HDL Ratio Total cholesterol/HDL Apo B/Apo A1 Conjugated estrogens Medroxyprogesterone acetate |
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