Effect of antioxidants and antibiotics on levels of seminal oxidative stress in leukocytospermic infertile men |
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| Authors: | Sunil B Yadav Adinath N Suryakar Anil D Huddedar Pramod S Shukla |
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| Institution: | (1) Department of Biochemistry, Krishna Institute of Medical Sciences, Karad, (MS), India;(2) Department of Urosurgery, Krishna Institute of Medical Sciences, Karad, (MS), India;(3) Department of Biochemistry, Dr. V. M. Medical College, Solapur, (MS), India |
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| Abstract: | Defective sperm function is the most common cause of infertility. A prospective study was carried out to correlate the concentration
of nitrite (the stable metabolite of nitric oxide) in seminal plasma with leukocytospermia, and sperm membrane integrity.
Total Fifty-seven normozoospermic subjects with and without leukocytospermia visiting the Infertility clinic at KH and MRC,
Karad, were included in the present study. Semen samples were checked for sperm concentration, total sperm count, sperm motility,
seminal leukocyte concentration and sperm membrane integrity as Hypoosmotic Swelling Test. Similarly the concentration of
nitrite in seminal plasma was measured by Griess reaction and total antioxidant power measured as ferric reducing ability
of plasma. The concentration of nitrite in seminal plasma was found to be raised with significantly increased leukocyte concentration
in semen. Also significantly lowered levels of total antioxidant power along with defective sperm function was observed. Our
results suggest that supplementary treatment of antioxidants with antibiotic for leukocytospermic infertile male patients
may improve the sperm membrane integrity. |
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| Keywords: | Leukocytes and Total antioxidant power Nitric oxide (as a nitrite) Sperm membrane integrity |
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